Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology.
A2ML1
FUT
fucosyltransferase
genetic
omic
otitis media (OM)
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
09
2019
accepted:
16
03
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
Otitis media (OM) is an infective and inflammatory disorder known to be a major cause of hearing impairment across all age groups. Both acute and chronic OM result in substantial healthcare utilization related to antibiotic prescription and surgical procedures necessary for its management. Although several studies provided evidence of genetics playing a significant role in the susceptibility to OM, we had limited knowledge about the genes associated with OM until recently. Here we have summarized the known genetic factors that confer susceptibility to various forms of OM in mice and in humans and their genetic load, along with associated cellular signaling pathways. Spotlighted in this review are fucosyltransferase (FUT) enzymes, which have been implicated in the pathogenesis of OM. A comprehensive understanding of the functions of OM-associated genes may provide potential opportunities for its diagnosis and treatment.
Identifiants
pubmed: 32391049
doi: 10.3389/fgene.2020.00313
pmc: PMC7191070
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
313Informations de copyright
Copyright © 2020 Giese, Ali, Isaiah, Aziz, Riazuddin and Ahmed.
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