Aging-associated genes
aging
mega-analysis
multiple linear regression model
pathway analysis
thyroid cancer
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
26
03
2019
accepted:
16
08
2019
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
ppublish
Résumé
The prevalence of thyroid cancer (TC) is high in the elderly. The present study was based on the hypothesis that genes, which have increased activity with aging, may play a role in the development of TC. A large-scale literature-based data analysis was conducted to explore the genes that are implicated in both TC and aging. Subsequently, a mega-analysis of 16 RNA expression datasets (1,222 samples: 439 healthy controls, and 783 patients with TC) was conducted to test a set of genes associated with aging but not TC. To uncover a possible link between these genes and TC, a functional pathway analysis was conducted, and the results were validated by analysis of gene co-expression. A multiple linear regression (MLR) model was employed to study the possible influence of sample size, population region and study age on the gene expression levels in TC. A total of 262 and 816 genes were identified to have increased activity with aging and TC, respectively; with a significant overlap of 63 genes (P<3.82×10
Identifiants
pubmed: 32391089
doi: 10.3892/ol.2020.11530
pii: OL-0-0-11530
pmc: PMC7204633
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3634-3642Informations de copyright
Copyright: © Lian et al.
Références
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19075-80
pubmed: 16365291
Biochem Biophys Res Commun. 2014 Apr 18;446(4):1219-1224
pubmed: 24680686
J Clin Endocrinol Metab. 2001 Apr;86(4):1447-63
pubmed: 11297567
J Clin Endocrinol Metab. 2013 Oct;98(10):E1645-54
pubmed: 23666977
Aging Cell. 2018 Jun;17(3):e12744
pubmed: 29504244
Oncogene. 2008 Apr 3;27(15):2228-36
pubmed: 17968324
Am J Pathol. 2012 Jul;181(1):111-20
pubmed: 22634180
Recent Pat Endocr Metab Immune Drug Discov. 2016;10(1):4-10
pubmed: 27396589
Cell Rep. 2013 Aug 29;4(4):830-41
pubmed: 23972995
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2803-8
pubmed: 17296934
Mol Cell Endocrinol. 2015 Mar 15;404:113-22
pubmed: 25643979
Mol Cell Biochem. 2003 Nov;253(1-2):241-6
pubmed: 14619975
PLoS One. 2015 Dec 01;10(12):e0143688
pubmed: 26625260
Thyroid. 2009 Aug;19(8):881-92
pubmed: 19645615
Br J Cancer. 2015 May 12;112(10):1665-74
pubmed: 25965298
Gerontology. 2015;61(4):291-300
pubmed: 25471682
Oncotarget. 2017 Sep 21;8(60):101475-101488
pubmed: 29254179
Int J Oncol. 2017 May;50(5):1567-1578
pubmed: 28393241
Cancer Res. 2007 Nov 1;67(21):10148-58
pubmed: 17981789
Curr Aging Sci. 2008 Jul;1(2):101-4
pubmed: 20021378
PLoS Genet. 2008 Jul 18;4(7):e1000129
pubmed: 18636107
Endocr Relat Cancer. 2016 Feb;23(2):113-24
pubmed: 26559672
Front Pharmacol. 2012 Jul 12;3:134
pubmed: 22807917
Invest Ophthalmol Vis Sci. 2014 Feb 10;55(2):801-13
pubmed: 24408972
Int J Mol Sci. 2017 Aug 11;18(8):
pubmed: 28800068
Aging Male. 2011 Jun;14(2):91-8
pubmed: 21087173
Thyroid. 2015 Oct;25(10):1106-14
pubmed: 26148759
J Biol Chem. 2005 Feb 4;280(5):3483-92
pubmed: 15611130
Oncogene. 2012 Oct 11;31(41):4490-8
pubmed: 22266856
Biochim Biophys Acta. 2016 Mar;1863(3):382-391
pubmed: 26079100
Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):1983-93
pubmed: 16609007
Br J Cancer. 2012 Sep 4;107(6):994-1000
pubmed: 22828612
Mol Vis. 2011;17:1261-74
pubmed: 21633715
Oncol Rep. 2016 Mar;35(3):1557-65
pubmed: 26707275
Eur J Nucl Med Mol Imaging. 2016 Jul;43(7):1267-77
pubmed: 26810418
Curr Mol Med. 2008 Dec;8(8):754-67
pubmed: 19075673
J Clin Endocrinol Metab. 2015 May;100(5):E697-709
pubmed: 25675381
Int J Chron Obstruct Pulmon Dis. 2018 Jan 30;13:409-418
pubmed: 29430175
Onco Targets Ther. 2017 Mar 22;10:1743-1755
pubmed: 28367057
Cell Death Dis. 2016 Jul 21;7:e2305
pubmed: 27441657
Oncogene. 2005 Oct 6;24(44):6646-56
pubmed: 16007166
JAMA. 2004 Dec 1;292(21):2651-4
pubmed: 15572724
Cancer Epidemiol Biomarkers Prev. 2017 Dec;26(12):1695-1704
pubmed: 29167277
Br J Cancer. 2009 Nov 17;101(10):1782-91
pubmed: 19809427
Virchows Arch. 2001 Feb;438(2):121-8
pubmed: 11253113
Aging (Albany NY). 2015 Jul;7(7):465-6
pubmed: 26187134
Endocr Relat Cancer. 2010 Jan 29;17(1):61-72
pubmed: 19808899
Expert Rev Proteomics. 2017 Apr;14(4):285-299
pubmed: 28281838
Cancer Res. 2001 Aug 15;61(16):6105-11
pubmed: 11507060
Laryngoscope. 2015 Apr;125(4):1021-7
pubmed: 25583017
World J Surg. 2018 Feb;42(2):350-357
pubmed: 29167950