Family history identifies sporadic schizoaffective disorder as a subtype for genetic studies.
familial-sporadic distinction
family history
genetic studies
novo genetic events
schizophrenia
Journal
The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa
ISSN: 1608-9685
Titre abrégé: S Afr J Psychiatr
Pays: South Africa
ID NLM: 100958626
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
03
2019
accepted:
19
12
2019
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
Schizophrenia is a heterogeneous disorder with strong genetic vulnerability. Family history of schizophrenia has been considered in genetic studies under several models. This study used the familial-sporadic distinction with the aim of identifying a more homogeneous phenotype to delineate the genetic and clinical complexity of schizophrenia. The study was conducted at Weskoppies Hospital, Pretoria, South Africa. The study included 384 participants with schizophrenia or schizoaffective disorder from the Afrikaner founder population in South Africa who are considered comparable to Caucasian patients from the United States. A comprehensive data capturing sheet was completed. When schizophrenia and schizoaffective disorder diagnoses were considered jointly, we found no significant differences between the sporadic and the familial groups for age at disease onset, season of birth, comorbid diagnoses, clinical symptomatology, history of suicide or marital status. When the diagnoses were examined separately, however, the sporadic schizoaffective disorder, bipolar type, was found to have a significantly lower age at onset (mean 20.6 vs. 25.3 years). The sporadic schizoaffective disorder, bipolar type, forms a more homogeneous subgroup for genetic studies.
Sections du résumé
BACKGROUND
BACKGROUND
Schizophrenia is a heterogeneous disorder with strong genetic vulnerability. Family history of schizophrenia has been considered in genetic studies under several models.
AIM
OBJECTIVE
This study used the familial-sporadic distinction with the aim of identifying a more homogeneous phenotype to delineate the genetic and clinical complexity of schizophrenia.
SETTING
METHODS
The study was conducted at Weskoppies Hospital, Pretoria, South Africa.
METHODS
METHODS
The study included 384 participants with schizophrenia or schizoaffective disorder from the Afrikaner founder population in South Africa who are considered comparable to Caucasian patients from the United States. A comprehensive data capturing sheet was completed.
RESULTS
RESULTS
When schizophrenia and schizoaffective disorder diagnoses were considered jointly, we found no significant differences between the sporadic and the familial groups for age at disease onset, season of birth, comorbid diagnoses, clinical symptomatology, history of suicide or marital status. When the diagnoses were examined separately, however, the sporadic schizoaffective disorder, bipolar type, was found to have a significantly lower age at onset (mean 20.6 vs. 25.3 years).
CONCLUSION
CONCLUSIONS
The sporadic schizoaffective disorder, bipolar type, forms a more homogeneous subgroup for genetic studies.
Identifiants
pubmed: 32391182
doi: 10.4102/sajpsychiatry.v26i0.1393
pii: SAJPsy-26-1393
pmc: PMC7203531
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1393Informations de copyright
© 2020. The Authors.
Déclaration de conflit d'intérêts
The authors have declared that no competing interest exists.
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