Digesting the crisis: autophagy and coronaviruses.
COVID-19
MERS
SARS
SARS-CoV-2
coronavirus
immunity
inflammation
virophagy
Journal
Microbial cell (Graz, Austria)
ISSN: 2311-2638
Titre abrégé: Microb Cell
Pays: Austria
ID NLM: 101632887
Informations de publication
Date de publication:
04 May 2020
04 May 2020
Historique:
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
Autophagy is a catabolic pathway with multifaceted roles in cellular homeostasis. This process is also involved in the antiviral response at multiple levels, including the direct elimination of intruding viruses (virophagy), the presentation of viral antigens, the fitness of immune cells, and the inhibition of excessive inflammatory reactions. In line with its central role in immunity, viruses have evolved mechanisms to interfere with or to evade the autophagic process, and in some cases, even to harness autophagy or constituents of the autophagic machinery for their replication. Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. In this piece, we provide a short overview of the evidence linking autophagy to coronaviruses and discuss whether such links may provide actionable targets for therapeutic interventions.
Identifiants
pubmed: 32391393
doi: 10.15698/mic2020.05.715
pii: MIC0270E122
pmc: PMC7199282
doi:
Types de publication
Journal Article
Langues
eng
Pagination
119-128Subventions
Organisme : Austrian Science Fund FWF
ID : W 1226
Pays : Austria
Informations de copyright
Copyright: © 2020 Carmona-Gutierrez et al.
Déclaration de conflit d'intérêts
Conflict of interest: D.C-G., G.K. and F.M. are the scientific co-founders of Samsara Therapeutics, a company that develops novel pharmacological autophagy inducers. A.Z. has equity interests in Samsara Therapeutics. F.M. and D.C-G. have equity interests in TLL (The Longevity Labs), a company that develops natural food extracts.
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