A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance.
DNA damage
DNA repair
metabolism
pentose phosphate pathway
redox
Journal
Molecular & cellular oncology
ISSN: 2372-3556
Titre abrégé: Mol Cell Oncol
Pays: United States
ID NLM: 101642411
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
01
2020
revised:
07
02
2020
accepted:
10
02
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.
Identifiants
pubmed: 32391425
doi: 10.1080/23723556.2020.1733383
pii: 1733383
pmc: PMC7199736
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1733383Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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