Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins.
DNA repair
DNA structure
Non-B DNA
cancer
mutagenesis
Journal
Molecular & cellular oncology
ISSN: 2372-3556
Titre abrégé: Mol Cell Oncol
Pays: United States
ID NLM: 101642411
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
03
2020
revised:
11
03
2020
accepted:
12
03
2020
entrez:
12
5
2020
pubmed:
12
5
2020
medline:
12
5
2020
Statut:
epublish
Résumé
Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different types of non-B DNA stimulate mutagenesis via distinct repair processing mechanisms.
Identifiants
pubmed: 32391433
doi: 10.1080/23723556.2020.1743807
pii: 1743807
pmc: PMC7199757
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1743807Subventions
Organisme : NCI NIH HHS
ID : R01 CA093729
Pays : United States
Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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