Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
14 Jun 2020
14 Jun 2020
Historique:
pubmed:
12
5
2020
medline:
22
1
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
TFF1 is a key peptide for gastrointestinal protection and repair. Its molecular mechanism of action remains poorly understood with synthetic intractability a recognised bottleneck. Here we describe the synthesis of TFF1 and its homodimer and their interactions with mucins and Helicobacter pylori. Synthetic access to TFF1 is an important milestone for probe and therapeutic development.
Identifiants
pubmed: 32391824
doi: 10.1039/d0cc02321c
pmc: PMC7116170
mid: EMS96565
doi:
Substances chimiques
Mucins
0
TFF1 protein, human
0
Trefoil Factor-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6420-6423Subventions
Organisme : European Research Council
ID : 714366
Pays : International
Commentaires et corrections
Type : ErratumIn
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