Effects of isotretinoin on glucose metabolism in patients with acne: A systematic review and meta-analysis.
Journal
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
ISSN: 1610-0387
Titre abrégé: J Dtsch Dermatol Ges
Pays: Germany
ID NLM: 101164708
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
07
07
2019
accepted:
01
10
2019
pubmed:
12
5
2020
medline:
16
6
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
Previous studies reporting the influence of isotretinoin treatment on glucose metabolism have produced conflicting results. We therefore aimed to examine the effects of isotretinoin treatment on changes in insulin resistance and serum levels of adiponectin in patients with acne. A systematic review and meta-analysis of the literature published from the inception of isotretinoin to March 31, 2019 were conducted. In the absence of controlled trials, open-label studies on acne patients receiving isotretinoin treatment were included. Twelve studies met the inclusion criteria. The outcomes included changes in the homeostasis model assessment for insulin resistance (HOMA-IR) values and serum levels of adiponectin after isotretinoin treatment. Pooled analysis showed that HOMA-IR values did not change significantly after isotretinoin treatment (standardized mean difference [SMD] = 0.183; 95 % confidence interval [CI] = -0.004-0.371; I
Substances chimiques
Adiponectin
0
Dermatologic Agents
0
Isotretinoin
EH28UP18IF
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
539-545Informations de copyright
© 2020 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.
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