Inconsistencies between measures of cognitive dysfunction in childhood acute lymphoblastic leukemia survivors: Description and understanding.
Adolescent
Adult
Anxiety
/ epidemiology
Attention
/ physiology
Canada
/ epidemiology
Cancer Survivors
/ psychology
Child
Cognitive Dysfunction
/ epidemiology
Cohort Studies
Emotions
Female
Humans
Male
Memory, Short-Term
/ physiology
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ psychology
Prevalence
Self Report
attention
cancer
childhood leukemia
cognitive test
oncology
self-report
survivors
working memory
Journal
Psycho-oncology
ISSN: 1099-1611
Titre abrégé: Psychooncology
Pays: England
ID NLM: 9214524
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
07
12
2019
revised:
24
03
2020
accepted:
05
05
2020
pubmed:
12
5
2020
medline:
22
12
2020
entrez:
12
5
2020
Statut:
ppublish
Résumé
The frequency of cognitive difficulties in childhood cancer survivors varies according to the measurement strategy. The goal of this research is to (a) describe agreements and differences between measures of working memory and attention (b) identify contributors of these differences, such as emotional distress, affects, and fatigue. We used data available for 138 adults successfully treated for childhood acute lymphoblastic leukemia (ALL) (PETALE cohort). Working memory and attention were assessed using subtests from the WAIS-IV and self-reported questionnaires (BRIEF-SR and CAARS-S:L). Potential contributors included emotional distress, anxiety, depression (BSI-18), affects (PANAS), and fatigue (PedsQL-MFS). We explored measurement agreements and differences using diagnostic indices and multivariate regression models. The frequencies of working memory and attention deficits were higher when using cognitive tests (15%-21%) than with self-reports (10%-11%). Self-reported questionnaires showed high specificity (median 0.87) and low sensitivity (median 0.10), suggesting they did not reliably identify positive cases on cognitive tests. We identified negative affectivity as a possible contributor to inconsistencies between self-report and test results. When measuring working memory and attention in childhood ALL survivors, cognitive test results and self-reports should not be considered equivalent. At best, self-report may be used for screening (high specificity), but not to assess prevalence in large samples. Self-reported difficulties are also probably influenced by the negative mood in this population.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1201-1208Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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