Long-distance regressive signaling in neural development and disease.
axon transport
degeneration
neurotrophin
p75NTR
signaling
Journal
Wiley interdisciplinary reviews. Developmental biology
ISSN: 1759-7692
Titre abrégé: Wiley Interdiscip Rev Dev Biol
Pays: United States
ID NLM: 101576624
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
02
10
2019
revised:
23
03
2020
accepted:
06
04
2020
pubmed:
12
5
2020
medline:
25
12
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
Nervous system development proceeds via well-orchestrated processes involving a balance between progressive and regressive events including stabilization or elimination of axons, synapses, and even entire neurons. These progressive and regressive events are driven by functionally antagonistic signaling pathways with the dominant pathway eventually determining whether a neural element is retained or removed. Many of these developmental sculpting events are triggered by final target innervation necessitating a long-distance mode of communication. While long-distance progressive signaling has been well characterized, particularly for neurotrophic factors, there remains relatively little known about how regressive events are triggered from a distance. Here we discuss the emergent phenomenon of long-distance regressive signaling pathways. In particular, we will cover (a) progressive and regressive cues known to be employed after target innervation, (b) the mechanisms of long-distance signaling from an endosomal platform, (c) recent evidence that long-distance regressive cues emanate from platforms like death receptors or repulsive axon guidance receptors, and (d) evidence that these pathways are exploited in pathological scenarios. This article is categorized under: Nervous System Development > Vertebrates: General Principles Signaling Pathways > Global Signaling Mechanisms Establishment of Spatial and Temporal Patterns > Cytoplasmic Localization.
Identifiants
pubmed: 32391977
doi: 10.1002/wdev.382
pmc: PMC7655682
mid: NIHMS1640413
doi:
Substances chimiques
Nerve Growth Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e382Subventions
Organisme : NINDS NIH HHS
ID : R01 NS102365
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091617
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107456
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008715
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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