Discovery of DS-1971a, a Potent, Selective Na

Analgesics / chemical synthesis Animals Drug Discovery Female Humans Hyperalgesia / drug therapy Macaca fascicularis Male Mice Microsomes, Liver / metabolism Molecular Structure NAV1.7 Voltage-Gated Sodium Channel / metabolism Pyrazoles / chemical synthesis Pyrimidines / chemical synthesis Structure-Activity Relationship Sulfonamides / chemical synthesis Voltage-Gated Sodium Channel Blockers / chemical synthesis

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
24 09 2020
Historique:
pubmed: 12 5 2020
medline: 5 1 2021
entrez: 12 5 2020
Statut: ppublish

Résumé

A highly potent, selective Na

Identifiants

DOI: 10.1021/acs.jmedchem.0c00259 PMID: 32392056
pubmed: 32392056
doi: 10.1021/acs.jmedchem.0c00259
doi:

Substances chimiques

Analgesics 0
DS-1971a 0
NAV1.7 Voltage-Gated Sodium Channel 0
Pyrazoles 0
Pyrimidines 0
SCN9A protein, human 0
Scn9a protein, mouse 0
Sulfonamides 0
Voltage-Gated Sodium Channel Blockers 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

10204-10220

Auteurs

Tsuyoshi Shinozuka (T)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
ORCID: 0000-0002-7785-6080

Hiroyuki Kobayashi (H)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Sayaka Suzuki (S)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Kyosuke Tanaka (K)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Narayan Karanjule (N)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Noriyuki Hayashi (N)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Toshifumi Tsuda (T)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Eri Tokumaru (E)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Masahiro Inoue (M)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Kiyono Ueda (K)

R&D Division, Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan.

Hiroko Kimoto (H)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Yuki Domon (Y)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Sakiko Takahashi (S)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Kazufumi Kubota (K)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Tomihisa Yokoyama (T)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Akiko Shimizugawa (A)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Ryuta Koishi (R)

R&D Division, Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan.

Chie Fujiwara (C)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Daigo Asano (D)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Tomoko Sakakura (T)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Kiyoshi Takasuna (K)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Yasuyuki Abe (Y)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Toshiyuki Watanabe (T)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

Yutaka Kitano (Y)

R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Eucaryotes › Animaux › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles somatosensoriels › Hyperalgésie › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca fascicularis › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.7 › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Discovery of DS-1971a, a Potent, Selective Na
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Bloqueurs de canaux sodiques › Bloqueurs de canaux sodiques voltage-dépendants › Discovery of DS-1971a, a Potent, Selective Na