Radiobiology data of melanoma cells after low-energy neutron irradiation and boron compound administration.
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
01
10
2019
revised:
11
12
2019
accepted:
21
04
2020
pubmed:
12
5
2020
medline:
11
8
2021
entrez:
12
5
2020
Statut:
ppublish
Résumé
The cold neutron beam at the PF1b line at the Institut Laue-Langevin (ILL), without fast neutrons and a low contribution of gamma rays, is a very suitable facility to measure cell damage following low-energy neutron irradiation. The biological damage associated with the thermal and the boron doses can be obtained in order to evaluate the relative biological effectiveness (RBE) for Boron Neutron Capture Therapy. Three different experiments were carried out on the A375 melanoma cell line: the first one in a hospital LINAC, to obtain the reference radiation data, and the other two at the ILL, in which the damage to cells with and without boron compounds added was measured.
Identifiants
pubmed: 32392166
pii: S0969-8043(20)30334-1
doi: 10.1016/j.apradiso.2020.109205
pii:
doi:
Substances chimiques
Boron Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109205Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.