Reduced complement of dopaminergic neurons in the substantia nigra pars compacta of mice with a constitutive "low footprint" genetic knockout of alpha-synuclein.

Animals Cell Survival / genetics Dopaminergic Neurons / metabolism Mice Mice, Inbred C57BL Mice, Knockout Pars Compacta / growth & development Substantia Nigra / cytology alpha-Synuclein / genetics
Alpha-synuclein Dopaminergic neurons Null mutant mice Striatum Substantia nigra

Journal

Molecular brain
ISSN: 1756-6606
Titre abrégé: Mol Brain
Pays: England
ID NLM: 101468876

Informations de publication

Date de publication:
11 05 2020
Historique:
received: 27 03 2020
accepted: 28 04 2020
entrez: 13 5 2020
pubmed: 13 5 2020
medline: 4 6 2021
Statut: epublish

Résumé

Previous studies of the alpha-synuclein null mutant mice on the C57Bl6 genetic background have revealed reduced number of dopaminergic neurons in their substantia nigra pars compacta (SNpc). However, the presence in genomes of the studied mouse lines of additional genetic modifications that affect expression of genes located in a close proximity to the alpha-synuclein-encoding Snca gene makes these data open to various interpretations. To unambiguously demonstrate that the absence of alpha-synuclein is the primary cause of the observed deficit of dopaminergic neurons, we employed a recently produced constituent alpha-synuclein knockout mouse line B6(Cg)-Snca

Identifiants

DOI: 10.1186/s13041-020-00613-5 PMID: 32393371 PMC: PMC7216632
pubmed: 32393371
doi: 10.1186/s13041-020-00613-5
pii: 10.1186/s13041-020-00613-5
pmc: PMC7216632
doi:

Substances chimiques

Snca protein, mouse 0
alpha-Synuclein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

75

Références

J Neurochem. 2004 Jun;89(5):1126-36
pubmed: 15147505
BMC Neurosci. 2001;2:11
pubmed: 11591219
Neurobiol Aging. 2020 Jul;91:76-87
pubmed: 32224067
Neuron. 2000 Jan;25(1):239-52
pubmed: 10707987
Neurobiol Aging. 2010 May;31(5):796-804
pubmed: 19097673
J Neurochem. 2020 Jan 20;:
pubmed: 31957016
PeerJ. 2018 May 16;6:e4779
pubmed: 29785351
Exp Neurol. 2013 Oct;248:541-5
pubmed: 23933574
Mol Cell Biol. 2003 Nov;23(22):8233-45
pubmed: 14585981
Sci Rep. 2015 Nov 13;5:16615
pubmed: 26564109
J Neurochem. 2019 Sep;150(5):475-486
pubmed: 31269263
Neurobiol Aging. 2016 Oct;46:107-12
pubmed: 27614017

Auteurs

Valeria V Goloborshcheva (VV)

School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), 1 Severniy proezd, Chernogolovka, Moscow Region, Russian Federation, 142432.

Kirill D Chaprov (KD)

School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), 1 Severniy proezd, Chernogolovka, Moscow Region, Russian Federation, 142432.

Ekaterina V Teterina (EV)

Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), 1 Severniy proezd, Chernogolovka, Moscow Region, Russian Federation, 142432.

Ruslan Ovchinnikov (R)

Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), 1 Severniy proezd, Chernogolovka, Moscow Region, Russian Federation, 142432.
Pirogov Russian National Research Medical University, Ostrovitianov Str., 1, Moscow, Russian Federation, 117997.

Vladimir L Buchman (VL)

School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK. buchmanvl@cf.ac.uk.
Institute of Physiologically Active Compounds Russian Academy of Sciences (IPAC RAS), 1 Severniy proezd, Chernogolovka, Moscow Region, Russian Federation, 142432. buchmanvl@cf.ac.uk.
ORCID: 0000-0002-7631-8352

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Reduced complement of dopaminergic neurons in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Reduced complement of dopaminergic neurons in...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Reduced complement of dopaminergic neurons in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Reduced complement of dopaminergic neurons in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Reduced complement of dopaminergic neurons in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Reduced complement of dopaminergic neurons in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Substantia nigra › Pars compacta › Reduced complement of dopaminergic neurons in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Substantia nigra › Reduced complement of dopaminergic neurons in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Reduced complement of dopaminergic neurons in...