Downregulation of p16 Decreases Biliary Damage and Liver Fibrosis in the Mdr2
ATP Binding Cassette Transporter, Subfamily B
/ genetics
Adult
Animals
Biliary Tract
/ metabolism
Cell Line
Cholangitis, Sclerosing
/ complications
Cyclin-Dependent Kinase Inhibitor p16
/ genetics
Down-Regulation
Female
Humans
Liver Cirrhosis
/ etiology
Male
Mice
MicroRNAs
/ genetics
Middle Aged
Sirtuin 1
/ metabolism
Transforming Growth Factor beta
/ metabolism
ATP-Binding Cassette Sub-Family B Member 4
Journal
Gene expression
ISSN: 1555-3884
Titre abrégé: Gene Expr
Pays: United States
ID NLM: 9200651
Informations de publication
Date de publication:
11 11 2020
11 11 2020
Historique:
pubmed:
13
5
2020
medline:
12
8
2021
entrez:
13
5
2020
Statut:
ppublish
Résumé
Biliary senescence and hepatic fibrosis are hallmarks of cholangiopathies including primary sclerosing cholangitis (PSC). Senescent cholangiocytes display senescence-associated secretory phenotypes [SASPs, e.g., transforming growth factor-1 (TGF-1)] that further increase biliary senescence (by an autocrine loop) and trigger liver fibrosis by paracrine mechanisms. The aim of this study was to determine the effect of p16 inhibition and role of the TGF-1/microRNA (miR)-34a/sirtuin 1 (SIRT1) axis in biliary damage and liver fibrosis in the Mdr2
Identifiants
pubmed: 32393417
doi: 10.3727/105221620X15889714507961
pmc: PMC7650011
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B
0
Cyclin-Dependent Kinase Inhibitor p16
0
MIRN34a microRNA, mouse
0
MicroRNAs
0
Transforming Growth Factor beta
0
Sirt1 protein, mouse
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-103Subventions
Organisme : NIAAA NIH HHS
ID : R21 AA025157
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK062975
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107310
Pays : United States
Organisme : BLRD VA
ID : I01 BX000574
Pays : United States
Organisme : BLRD VA
ID : I01 BX003031
Pays : United States
Organisme : BLRD VA
ID : IK6 BX004601
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108959
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA026385
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK119421
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA025997
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK110035
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK054811
Pays : United States
Organisme : BLRD VA
ID : I01 BX001724
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK076898
Pays : United States
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