Repeat RNAs associate with replication forks and post-replicative DNA.
DNA replication
RNA
chromatin
repeats
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
08
01
2020
accepted:
04
05
2020
pubmed:
13
5
2020
medline:
6
10
2020
entrez:
13
5
2020
Statut:
ppublish
Résumé
Noncoding RNA has a proven ability to direct and regulate chromatin modifications by acting as scaffolds between DNA and histone-modifying complexes. However, it is unknown if ncRNA plays any role in DNA replication and epigenome maintenance, including histone eviction and reinstallment of histone modifications after genome duplication. Isolation of nascent chromatin has identified a large number of RNA-binding proteins in addition to unknown components of the replication and epigenetic maintenance machinery. Here, we isolated and characterized long and short RNAs associated with nascent chromatin at active replication forks and track RNA composition during chromatin maturation across the cell cycle. Shortly after fork passage, GA-rich-, alpha- and TElomeric Repeat-containing RNAs (TERRA) are associated with replicated DNA. These repeat containing RNAs arise from loci undergoing replication, suggesting an interaction in
Identifiants
pubmed: 32393525
pii: rna.074757.120
doi: 10.1261/rna.074757.120
pmc: PMC7430672
doi:
Substances chimiques
Chromatin
0
Histones
0
RNA
63231-63-0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1104-1117Subventions
Organisme : European Research Council
ID : 281765
Pays : International
Informations de copyright
© 2020 Gylling et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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