Perinatal diet influences health and survival in a mouse model of leukemia.

Adiposity Lifespan Maternal gestational diets Perinatal interventions Post-natal environment

Journal

GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284

Informations de publication

Date de publication:
08 2020
Historique:
received: 02 02 2020
accepted: 29 04 2020
pubmed: 13 5 2020
medline: 28 4 2021
entrez: 13 5 2020
Statut: ppublish

Résumé

The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.

Identifiants

pubmed: 32394346
doi: 10.1007/s11357-020-00199-9
pii: 10.1007/s11357-020-00199-9
pmc: PMC7394991
doi:

Types de publication

Journal Article Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1147-1155

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Auteurs

Dushani L Palliyaguru (DL)

Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Suite 100, Baltimore, MD, 21224, USA.

Annamaria L Rudderow (AL)

Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Suite 100, Baltimore, MD, 21224, USA.

Alex M Sossong (AM)

Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Suite 100, Baltimore, MD, 21224, USA.

Kaitlyn N Lewis (KN)

Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Suite 100, Baltimore, MD, 21224, USA.

Caitlin Younts (C)

Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Suite 100, Baltimore, MD, 21224, USA.

Kevin J Pearson (KJ)

Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, USA.

Michel Bernier (M)

Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Suite 100, Baltimore, MD, 21224, USA.

Rafael de Cabo (R)

Translational Gerontology Branch, National Institute on Aging, NIH, 251 Bayview Blvd, Suite 100, Baltimore, MD, 21224, USA. decaboRa@mail.nih.gov.

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Classifications MeSH