Drug Nanocrystals: A Comprehensive Review with Current Regulatory Guidelines.
Drug nanocrystals
bioavailability
manufacturing methods
marketed products
physical and chemical stability
regulatory guideline
Journal
Current drug delivery
ISSN: 1875-5704
Titre abrégé: Curr Drug Deliv
Pays: United Arab Emirates
ID NLM: 101208455
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
01
2020
revised:
26
02
2020
accepted:
21
03
2020
pubmed:
13
5
2020
medline:
8
5
2021
entrez:
13
5
2020
Statut:
ppublish
Résumé
Drug nanocrystals offer an attractive approach for improving the solubility and dissolution rate of poorly soluble drugs which accounts for nearly 40 % newly discovered drug molecules. Both methods for manufacturing drug nanocrystals have high industrial acceptability for being simple and easy to scale which is evident from the number of approved products available in the market. Ability to modify multiple aspects of dosage form like bioavailability, release pattern and dosage form requirement along with flexibility in choosing final dosage form starting from the tablet, capsule, suspension to parenteral one, have made nanocrystal technology one of the very promising and adaptable technology for dosage form design.
Identifiants
pubmed: 32394834
pii: CDD-EPUB-106560
doi: 10.2174/1567201817666200512104833
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
470-482Informations de copyright
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