The role of exercise in brain DNA damage.
DNA damage
DNA repair
aerobic exercise
apoptosis
brain
brain-derived neurotrophic factor
neurodegenerative disease
oxidative stress
physical exercise
strength exercise
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
13
5
2020
Statut:
ppublish
Résumé
Cells are constantly subjected to cytotoxic and genotoxic insults resulting in the accumulation of unrepaired damaged DNA, which leads to neuronal death. In this way, DNA damage has been implicated in the pathogenesis of neurological disorders, cancer, and aging. Lifestyle factors, such as physical exercise, are neuroprotective and increase brain function by improving cognition, learning, and memory, in addition to regulating the cellular redox milieu. Several mechanisms are associated with the effects of exercise in the brain, such as reduced production of oxidants, up-regulation of antioxidant capacity, and a consequent decrease in nuclear DNA damage. Furthermore, physical exercise is a potential strategy for further DNA damage repair. However, the neuroplasticity molecules that respond to different aspects of physical exercise remain unknown. In this review, we discuss the influence of exercise on DNA damage and adjacent mechanisms in the brain. We discuss the results of several studies that focus on the effects of physical exercise on brain DNA damage.
Identifiants
pubmed: 32394945
pii: NeuralRegenRes_2020_15_11_1981_282237
doi: 10.4103/1673-5374.282237
pmc: PMC7716049
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1981-1985Déclaration de conflit d'intérêts
None
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