Amyloid-beta peptide neurotoxicity in human neuronal cells is associated with modulation of insulin-like growth factor transport, lysosomal machinery and extracellular matrix receptor interactions.
Alzheimer’s disease
SH-SY5Y cells
amyloid
lysosomes
neurodegeneration
oxidative stress
proteomics
ribosome
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
13
5
2020
Statut:
ppublish
Résumé
Extracellular deposits of the amyloid-beta peptide (Aβ) are known as the main pathological hallmark of Alzheimer's disease. In Alzheimer's disease, neurons are injured and die throughout the brain, a process in which Aβ neurotoxicity is considered to play an important role. However, the molecular mechanisms underlying Aβ toxicity that lead to neurodegeneration are not clearly established. Here we have elucidated the molecular pathways and networks which are impacted by Aβ in neurons using SH-SY5Y human neuroblastoma cells as a model. These cells were treated with Aβ
Identifiants
pubmed: 32394972
pii: NeuralRegenRes_2020_15_11_2131_282261
doi: 10.4103/1673-5374.282261
pmc: PMC7716038
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2131-2142Déclaration de conflit d'intérêts
None
Références
Neural Regen Res. 2020 Feb;15(2):257-258
pubmed: 31552893
Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20057-62
pubmed: 19897719
Nat Protoc. 2013 Aug;8(8):1551-66
pubmed: 23868073
Expert Opin Ther Targets. 2016 Dec;20(12):1393-1395
pubmed: 27805462
Neurosci Bull. 2014 Apr;30(2):271-81
pubmed: 24664866
Mt Sinai J Med. 2010 Jan-Feb;77(1):59-68
pubmed: 20101724
Science. 2004 Oct 15;306(5695):457-61
pubmed: 15486293
Med Princ Pract. 2015;24(1):1-10
pubmed: 25471398
Semin Immunopathol. 2018 Jan;40(1):113-124
pubmed: 29134267
J Neurosci. 2005 Oct 5;25(40):9171-5
pubmed: 16207876
Brain. 2009 Apr;132(Pt 4):833-42
pubmed: 19336460
Essays Biochem. 2014;56:99-110
pubmed: 25131589
Acta Neuropathol. 2009 Jul;118(1):181-95
pubmed: 19259691
Lancet. 2003 Apr 12;361(9365):1258-65
pubmed: 12699953
EMBO Rep. 2010 Nov;11(11):861-7
pubmed: 20890309
Am J Physiol Endocrinol Metab. 2012 Dec 1;303(11):E1363-72
pubmed: 23032687
Nat Commun. 2017 Sep 11;8(1):512
pubmed: 28894090
Mol Neurobiol. 2019 Sep;56(9):6017-6034
pubmed: 30707393
J Neurochem. 2015 Jun;133(5):739-49
pubmed: 25645581
Nat Genet. 2006 May;38(5):500-1
pubmed: 16642009
NeuroRx. 2004 Jan;1(1):117-27
pubmed: 15717012
Nat Neurosci. 2009 Feb;12(2):119-21
pubmed: 19122666
Neuropathol Appl Neurobiol. 2017 Feb;43(2):167-182
pubmed: 26544797
Neurosci Lett. 2002 Jan 4;317(1):13-6
pubmed: 11750985
Curr Neuropharmacol. 2009 Mar;7(1):1-8
pubmed: 19721814
Neurobiol Aging. 2002 Nov-Dec;23(6):1073-4
pubmed: 12470803
J Alzheimers Dis. 2010;19(1):311-23
pubmed: 20061647
J Biol Chem. 2011 Sep 30;286(39):34088-100
pubmed: 21832049
Neurotherapeutics. 2015 Jan;12(1):3-11
pubmed: 25371168
Front Mol Neurosci. 2019 Feb 22;12:24
pubmed: 30853886
Sci Rep. 2017 Dec 4;7(1):16855
pubmed: 29203899
Neural Regen Res. 2018 Dec;13(12):2100-2101
pubmed: 30323135
Neurobiol Aging. 2006 Sep;27(9):1224-38
pubmed: 16122841
Cell Death Discov. 2018 Feb 20;4:31
pubmed: 29531828
Nat Rev Neurol. 2015 Aug;11(8):457-70
pubmed: 26195256
Exp Mol Med. 2017 Nov 17;49(11):e391
pubmed: 29147009
Mol Cell Biol. 2011 Oct;31(19):3975-87
pubmed: 21791607
Sci Rep. 2017 Aug 21;7(1):8412
pubmed: 28827627
Toxicol Appl Pharmacol. 2008 Feb 1;226(3):236-43
pubmed: 17980396
Methods Mol Biol. 2017;1549:45-66
pubmed: 27975283
J Neurosci. 2016 Jan 20;36(3):1001-7
pubmed: 26791227
PLoS One. 2016 Nov 30;11(11):e0167428
pubmed: 27902765
JCI Insight. 2017 Aug 17;2(16):
pubmed: 28814675
PLoS One. 2009 Oct 14;4(10):e7454
pubmed: 19829701
Neural Regen Res. 2018 Apr;13(4):595-598
pubmed: 29722301
PLoS One. 2017 Oct 24;12(10):e0186636
pubmed: 29065138
J Alzheimers Dis. 2017;57(4):1105-1121
pubmed: 28059794
J Biomed Biotechnol. 2002;2(3):120-123
pubmed: 12488575
J Neurosci. 2016 Nov 16;36(46):11693-11703
pubmed: 27852777
BMC Med Genomics. 2010 Aug 13;3:37
pubmed: 20707922
EBioMedicine. 2016 Apr;6:42-49
pubmed: 27211547
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14670-5
pubmed: 19667196
Cell. 2016 Feb 11;164(4):603-15
pubmed: 26871627
Front Aging Neurosci. 2018 Jun 14;10:180
pubmed: 29962946
Invest Ophthalmol Vis Sci. 2014 Apr 17;55(5):3060-6
pubmed: 24744204
J Cell Sci. 2010 Dec 15;123(Pt 24):4195-200
pubmed: 21123617
PLoS One. 2015 Apr 15;10(4):e0122889
pubmed: 25875231
Neuron. 2017 Sep 27;96(1):115-129.e5
pubmed: 28957663
J Alzheimers Dis. 2010;22(3):741-63
pubmed: 20847424
Rev Neurosci. 2015;26(4):385-95
pubmed: 25870960
Front Aging Neurosci. 2018 Jan 30;10:04
pubmed: 29441009
Biochimie. 2008 May;90(5):749-61
pubmed: 18261994
Alzheimers Dement (Amst). 2018 Aug 10;10:545-553
pubmed: 30370330
Sci Rep. 2017 Oct 4;7(1):12685
pubmed: 28978942
Prog Neurobiol. 2000 Feb;60(2):139-65
pubmed: 10639052
Biochem Biophys Res Commun. 2014 Nov 21;454(3):381-6
pubmed: 25451258
Int J Mol Sci. 2018 Dec 30;20(1):
pubmed: 30598025
Neuroimage. 2011 Jan;54 Suppl 1:S204-17
pubmed: 20550967
J Alzheimers Dis. 2010;20(4):1069-82
pubmed: 20413890
Sci Rep. 2018 Jan 10;8(1):354
pubmed: 29321508
J Neurochem. 2003 Sep;86(6):1313-27
pubmed: 12950441