Ciprofloxacin: single versus multiple doses in transrectal ultrasound guided prostate biopsy.
antibiotics
transrectal ultrasound guided prostate biopsy
Journal
Central European journal of urology
ISSN: 2080-4806
Titre abrégé: Cent European J Urol
Pays: Poland
ID NLM: 101587101
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
11
2019
revised:
23
02
2020
accepted:
23
02
2020
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
13
5
2020
Statut:
ppublish
Résumé
There is rising concern regarding overuse of fluoroquinolones due to severe musculoskeletal and neurological side effects, and development of resistant microorganisms. In June 2019, the European Commission recommended fluoroquinolones should not be used routinely for prophylaxis in urological surgical procedures. Methods to reduce unnecessary exposure to fluroquinolones should be investigated.The aim of this article was to determine differences in hospital admission secondary to sepsis following transrectal ultrasound (TRUS) guided prostate biopsies between patients who received single vs. multiple doses of fluoroquinolones. A retrospective analysis (June 2017-September 2018) of 200 consecutive TRUS biopsies at a single centre was undertaken. Group 1 (n = 100) received 750 mg ciprofloxacin 1-hr before their procedure followed by 3 days of ciprofloxacin 250 mg BD. Group 2 (n = 100) received a single dose of 750 mg ciprofloxacin 1-hr before the procedure. Midstream urine (MSU) culture results were examined pre-biopsy and 7 days post-biopsy. Data was also gathered on readmission rates to hospital as a result of urosepsis. A total of 1% of patients in each group required hospital admission secondary to Escherichia coli sepsis. A further 4% (n = 4) in Group 1 developed a urinary tract infection requiring antibiotic treatment post biopsy compared with 1% (n = 1) in Group 2. There was no statistically significant difference in development of infectious complications post-biopsy between the two groups (p >0.05). A single prophylactic dose of 750 mg of ciprofloxacin 1-hour pre-biopsy is as effective as multiple doses for TRUS guided prostate biopsy. Avoiding an unnecessary and prolonged course of fluoroquinolones has advantages in reducing potential side effects and development of resistant pathogens.
Identifiants
pubmed: 32395330
doi: 10.5173/ceju.2020.0067
pii: 0067
pmc: PMC7203767
doi:
Types de publication
Journal Article
Langues
eng
Pagination
91-93Informations de copyright
Copyright by Polish Urological Association.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
BJU Int. 2015 Oct;116 Suppl 3:49-53
pubmed: 26176815
Can J Infect Dis Med Microbiol. 2018 Feb 8;2018:3747521
pubmed: 29670677
BJU Int. 2013 May;111(6):946-53
pubmed: 23464844
J Urol. 2008 Mar;179(3):952-5; discussion 955
pubmed: 18207185
Int J Syst Evol Microbiol. 2016 Dec;66(12):5575-5599
pubmed: 27620848
Eur Urol. 2008 Dec;54(6):1270-86
pubmed: 18423974
BJU Int. 2012 Jun;109(12):1781-5
pubmed: 22040349
Medicina (Kaunas). 2019 Jul 09;55(7):
pubmed: 31324035
Medchemcomm. 2019 Jun 28;10(10):1719-1739
pubmed: 31803393
BJU Int. 2000 Apr;85(6):682-5
pubmed: 10759665
J Chemother. 2008 Apr;20(2):213-8
pubmed: 18467248
Eur Urol. 2013 Dec;64(6):876-92
pubmed: 23787356
Cent European J Urol. 2015;68(2):229-31
pubmed: 26251751