Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection.
Autophagy
Cathelicidin
Immunity
Infections
Inflammation
Vitamin D
Journal
Immune network
ISSN: 1598-2629
Titre abrégé: Immune Netw
Pays: Korea (South)
ID NLM: 101137270
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
27
10
2019
revised:
28
01
2020
accepted:
30
01
2020
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
13
5
2020
Statut:
epublish
Résumé
Vitamin D signaling plays an essential role in innate defense against intracellular microorganisms via the generation of the antimicrobial protein cathelicidin. In addition to directly binding to and killing a range of pathogens, cathelicidin acts as a secondary messenger driving vitamin D-mediated inflammation during infection. Recent studies have elucidated the biological and clinical functions of cathelicidin in the context of vitamin D signaling. The vitamin D-cathelicidin axis is involved in the activation of autophagy, which enhances antimicrobial effects against diverse pathogens. Vitamin D studies have also revealed positive and negative regulatory effects of cathelicidin on inflammatory responses to pathogenic stimuli. Diverse innate and adaptive immune signals crosstalk with functional vitamin D receptor signals to enhance the role of cathelicidin action in cell-autonomous effector systems. In this review, we discuss recent findings that demonstrate how the vitamin D-cathelicidin pathway regulates autophagy machinery, protective immune defenses, and inflammation, and contributes to immune cooperation between innate and adaptive immunity. Understanding how the vitamin D-cathelicidin axis operates in the host response to infection will create opportunities for the development of new therapeutic approaches against a variety of infectious diseases.
Identifiants
pubmed: 32395364
doi: 10.4110/in.2020.20.e12
pmc: PMC7192829
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e12Informations de copyright
Copyright © 2020. The Korean Association of Immunologists.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors declare no potential conflicts of interest.
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