The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation.
Butyrate
Hyperinflammation
Macrophages
Pro-inflammatory cytokines
Regulatory T-cells
Septic shock
Journal
Immune network
ISSN: 1598-2629
Titre abrégé: Immune Netw
Pays: Korea (South)
ID NLM: 101137270
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
16
08
2019
revised:
09
01
2020
accepted:
19
01
2020
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
13
5
2020
Statut:
epublish
Résumé
An excessive hyperinflammatory response-caused septic shock is a major medical problem that is associated with pathogenic bacterial infections leading to high mortality rates. The intestinal microbiota and the associated elaborated metabolites such as short chain fatty acid butyrate have been shown to relieve pathogenic bacterial-caused acute inflammation. Butyrate can down-regulate inflammation by inhibiting the growth of pathobionts, increasing mucosal barrier integrity, encouraging obligate anaerobic bacterial dominance and decreasing oxygen availability in the gut. Butyrate can also decrease excessive inflammation through modulation of immune cells such as increasing functionalities of M2 macrophages and regulatory T cells and inhibiting infiltration by neutrophils. Therefore, various approaches can be used to increase butyrate to relieve pathogenic bacterial-caused hyperinflammation. In this review we summarize the roles of butyrate in attenuating pathogenic bacterial-caused hyperinflammatory responses and discuss the associated plausible mechanisms.
Identifiants
pubmed: 32395367
doi: 10.4110/in.2020.20.e15
pmc: PMC7192831
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e15Informations de copyright
Copyright © 2020. The Korean Association of Immunologists.
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors declare no potential conflicts of interest.
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