Does the conventional dosage of linezolid necessitate therapeutic drug monitoring?-Experience from a prospective observational study.
Linezolid
overexposure
renal function
therapeutic drug monitoring (TDM)
underexposure
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
13
5
2020
Statut:
ppublish
Résumé
The objectives of the present prospective observational study conducted in patients receiving conventional dosage of linezolid was to define the pharmacodynamic range of linezolid exposure, to assess the inter-individual variability in linezolid concentrations, and to define if therapeutic drug monitoring (TDM) of linezolid may be necessary for Chinese population. Patients included in this study underwent linezolid TDM trough concentration ( A total of 84 patients who had 153 linezolid Our results suggest that the pharmacodynamic range of linezolid
Sections du résumé
BACKGROUND
BACKGROUND
The objectives of the present prospective observational study conducted in patients receiving conventional dosage of linezolid was to define the pharmacodynamic range of linezolid exposure, to assess the inter-individual variability in linezolid concentrations, and to define if therapeutic drug monitoring (TDM) of linezolid may be necessary for Chinese population.
METHODS
METHODS
Patients included in this study underwent linezolid TDM trough concentration (
RESULTS
RESULTS
A total of 84 patients who had 153 linezolid
CONCLUSIONS
CONCLUSIONS
Our results suggest that the pharmacodynamic range of linezolid
Identifiants
pubmed: 32395537
doi: 10.21037/atm.2020.03.207
pii: atm-08-07-493
pmc: PMC7210126
doi:
Types de publication
Journal Article
Langues
eng
Pagination
493Informations de copyright
2020 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm.2020.03.207). The authors have no conflicts of interest to declare.
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