Amyloid precursor protein processing in human neurons with an allelic series of the

amyloid beta Alzheimer’s disease CRISPR/Cas9 iPSCs

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2019
Historique:
entrez: 13 5 2020
pubmed: 1 1 2019
medline: 1 1 2019
Statut: ppublish

Résumé

Mutations in presenilin-1 (

Identifiants

pubmed: 32395715
doi: 10.1093/braincomms/fcz024
pmc: PMC7212081
mid: EMS86351
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcz024

Subventions

Organisme : Medical Research Council
ID : MR/K01417X/1
Pays : United Kingdom
Organisme : EPA
ID : EP-C-18-008
Pays : United States
Organisme : Parkinson's UK
ID : G-0907
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026004/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M02492X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701075
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0901254
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0900421
Pays : United Kingdom

Déclaration de conflit d'intérêts

Competing interests The authors report no competing interests.

Références

Cell Rep. 2016 Mar 8;14(9):2263-2272
pubmed: 26923600
Hum Mol Genet. 1999 Aug;8(8):1529-40
pubmed: 10401002
Nature. 2019 Jan;565(7738):192-197
pubmed: 30598546
Neuron. 2006 Sep 21;51(6):703-14
pubmed: 16982417
J Biol Chem. 2002 May 24;277(21):19236-40
pubmed: 11943765
J Alzheimers Dis. 2011;25(1):3-28
pubmed: 21335653
Science. 2019 Feb 15;363(6428):
pubmed: 30630874
EMBO J. 2012 May 16;31(10):2261-74
pubmed: 22505025
Neuron. 2016 Apr 20;90(2):417-22
pubmed: 27100200
Nat Neurosci. 2002 Sep;5(9):849-55
pubmed: 12145638
J Biol Chem. 2015 Jun 12;290(24):15078-91
pubmed: 25897080
Cell Rep. 2015 May 5;11(5):689-96
pubmed: 25921538
ACS Med Chem Lett. 2010 Mar 22;1(3):120-4
pubmed: 24900185
Trends Pharmacol Sci. 1991 Oct;12(10):383-8
pubmed: 1763432
Cell. 2017 Jul 27;170(3):443-456.e14
pubmed: 28753424
Neuron. 2019 Dec 4;104(5):1022
pubmed: 31805257
Nature. 2016 May 5;533(7601):125-9
pubmed: 27120160
Cell. 2016 Jun 30;166(1):193-208
pubmed: 27293189
J Neurosci. 2009 Oct 14;29(41):13042-52
pubmed: 19828817
Lancet Neurol. 2016 Dec;15(13):1326-1335
pubmed: 27777022
EMBO J. 2019 Jun 17;38(12):
pubmed: 31109937
Neuron. 2016 Apr 20;90(2):410-6
pubmed: 27100199
J Exp Med. 2015 Nov 16;212(12):2003-13
pubmed: 26481686
Mol Psychiatry. 2019 Apr 12;:
pubmed: 30980041
Nature. 1998 Jan 22;391(6665):387-90
pubmed: 9450754
J Biol Chem. 2019 Jul 19;294(29):11276-11285
pubmed: 31167792
Nature. 2018 Nov;563(7733):646-651
pubmed: 30405244
Cell Rep. 2013 Nov 27;5(4):974-85
pubmed: 24239350
Am J Hum Genet. 1998 Jan;62(1):70-6
pubmed: 9443865
J Biol Chem. 2014 Feb 21;289(8):5109-21
pubmed: 24375443
Nat Neurosci. 2012 Feb 05;15(3):477-86, S1
pubmed: 22306606
Science. 2010 Nov 19;330(6007):1065
pubmed: 20929727
Neuron. 2003 Apr 10;38(1):9-12
pubmed: 12691659
Bioinformatics. 2015 Sep 15;31(18):3078-80
pubmed: 25979474

Auteurs

Charles Arber (C)

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.

Claudio Villegas-Llerena (C)

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.
Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.

Jamie Toombs (J)

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.
UK Dementia Research Institute at UCL, London, UK.

Jennifer M Pocock (JM)

Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.

Natalie S Ryan (NS)

Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.

Nick C Fox (NC)

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.
UK Dementia Research Institute at UCL, London, UK.
Department of Neurodegenerative Disease, Dementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.

Henrik Zetterberg (H)

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.
UK Dementia Research Institute at UCL, London, UK.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mo¨ lndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

John Hardy (J)

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.
UK Dementia Research Institute at UCL, London, UK.

Selina Wray (S)

Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 1PJ, UK.

Classifications MeSH