Asymmetric Linear-Selective Hydroformylation of 1,1-Dialkyl Olefins Assisted by a Steric-Auxiliary Strategy.

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
05 06 2020
Historique:
pubmed: 13 5 2020
medline: 13 5 2020
entrez: 13 5 2020
Statut: ppublish

Résumé

Asymmetric hydroformylation of 1,2-dialkyl olefins was reported. In order to increase the enantiomeric induction, steric auxiliary sulfonyl groups were introduced. Using a Rh/Yanphos complex as catalyst, chiral aldehydes were obtained with high enantioselectivities under mild pressure. The easily removable auxiliary made this method a powerful tool in the preparation of important enantiopure building blocks.

Identifiants

DOI: 10.1021/acs.orglett.0c01550 PMID: 32396011
pubmed: 32396011
doi: 10.1021/acs.orglett.0c01550
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4523-4526

Auteurs

Dequan Zhang (D)

Shenzhen Grubbs Institute and Department of Chemistry, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055, China.

Cai You (C)

Shenzhen Grubbs Institute and Department of Chemistry, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055, China.

Xiuxiu Li (X)

Shenzhen Grubbs Institute and Department of Chemistry, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055, China.

Jialin Wen (J)

Shenzhen Grubbs Institute and Department of Chemistry, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055, China.
Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055, China.
ORCID: 0000-0003-3328-3265

Xumu Zhang (X)

Shenzhen Grubbs Institute and Department of Chemistry, Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, 518055, China.
ORCID: 0000-0001-5700-0608

Classifications MeSH