A fentanyl vaccine constructed upon opsonizing antibodies specific for the Galα1-3Gal epitope.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
18 Jun 2020
18 Jun 2020
Historique:
pubmed:
13
5
2020
medline:
22
1
2021
entrez:
13
5
2020
Statut:
ppublish
Résumé
A double conjugation strategy was implemented to produce an anti-fentanyl vaccine, which was predicated upon preformed-antibody-assisted antigen presentation. The new vaccine was found to reduce the psychoactive effects of fentanyl without the addition of the immunostimulant CpG oligodeoxynucleotide.
Identifiants
pubmed: 32396160
doi: 10.1039/d0cc02107e
pmc: PMC7398699
mid: NIHMS1595344
doi:
Substances chimiques
Antibodies
0
Disaccharides
0
Epitopes
0
Vaccines, Synthetic
0
galactosyl-(1-3)galactose
13168-24-6
Fentanyl
UF599785JZ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6551-6554Subventions
Organisme : NIDA NIH HHS
ID : UH3 DA041146
Pays : United States
Références
J Immunol. 1992 Dec 1;149(11):3477-81
pubmed: 1431118
Annu Rev Immunol. 2002;20:709-60
pubmed: 11861616
JAMA. 2018 May 1;319(17):1819-1821
pubmed: 29715347
Biochemistry. 2017 Oct 24;56(42):5625-5627
pubmed: 28994583
Toxicol Appl Pharmacol. 1964 Jan;6:48-62
pubmed: 14105897
Nature. 1975 Feb 13;253(5492):565-6
pubmed: 1117991
Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3772-5
pubmed: 26879590
J Pharmacol Exp Ther. 2019 Feb;368(2):282-291
pubmed: 30409833
Annu Rev Immunol. 1999;17:593-623
pubmed: 10358769
Expert Opin Drug Saf. 2007 Mar;6(2):125-32
pubmed: 17367258
ACS Chem Neurosci. 2018 Jun 20;9(6):1269-1275
pubmed: 29558798
Org Biomol Chem. 2017 Apr 5;15(14):2979-2992
pubmed: 28294277
J Virol. 2006 Jul;80(14):6943-51
pubmed: 16809300
N Engl J Med. 2017 Jul 27;377(4):391-394
pubmed: 28564549
Vaccine. 2009 May 18;27(23):3072-82
pubmed: 19428921
Br J Anaesth. 1962 Apr;34:260-8
pubmed: 14451235
Nat Rev Immunol. 2008 Jan;8(1):34-47
pubmed: 18064051
J Biol Chem. 1995 Sep 15;270(37):21437-40
pubmed: 7545161
Cancer Res. 1999 Jul 15;59(14):3417-23
pubmed: 10416604
Chem Commun (Camb). 2017 Jul 18;53(58):8156-8159
pubmed: 28677711
J Pharmacol Exp Ther. 2006 Mar;316(3):1195-201
pubmed: 16291875
Immunol Cell Biol. 2004 Oct;82(5):488-96
pubmed: 15479434
J Virol. 2007 Sep;81(17):9131-41
pubmed: 17609270
Drug Alcohol Depend. 2017 Feb 01;171:107-116
pubmed: 28068563
Proc Natl Acad Sci U S A. 1987 Mar;84(5):1369-73
pubmed: 2434954
ACS Omega. 2018 Sep 30;3(9):11537-11543
pubmed: 30288464
Expert Rev Vaccines. 2011 Jul;10(7):1053-61
pubmed: 21806399
J Immunol. 1963 Dec;91:761-70
pubmed: 14106299