Pluronic P123 modified nano micelles loaded with doxorubicin enhanced tumor-suppressing effect on drug-resistant breast cancer cells.

Antibiotics, Antineoplastic / pharmacology Apoptosis / drug effects Breast Neoplasms / drug therapy Cell Line, Tumor Cell Survival / drug effects Doxorubicin / pharmacology Drug Delivery Systems Drug Resistance, Neoplasm Female Humans Micelles Poloxalene / administration & dosage
P-glycoprotein Pluronic P123 modification breast cancer multi-drug resistance nano micelles

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
12 05 2020
Historique:
received: 11 01 2020
accepted: 31 03 2020
pubmed: 13 5 2020
medline: 26 2 2021
entrez: 13 5 2020
Statut: ppublish

Résumé

Nano micelles (NMs) have been widely used for various biomedical applications due to its unique physiochemical properties. This study aimed to investigated the anti-tumor effect of doxorubicin (Dox)-loaded Pluronic P123 (P123) and PEG2000-DSPE mixed NMs in drug-resistant breast cancer cells. The expression of P-gp and MDR1 gene was highly expressed in MCF-7R but not MCF-7 cells. The cellular uptake of P123-PEG2000-DSPE (Dox) was higher than that of free Dox and PEG2000-DSPE (Dox) in MCF-7R cells. Furthermore, compared with free Dox, both PEG2000-DSPE (Dox) and P123-PEG2000-DSPE (Dox) significantly diminished cell viability, and promoted cell apoptosis in MCF-7R cells. In addition, the P123-modified NMs obviously inhibited the expression of P-gp and MDR1. P123-PEG2000-DSPE (Dox) had a superior anti-tumor activity than PEG2000-DSPE (Dox) in MCF-7R cells through P-gp-mediated drug excretion and drug resistance mechanisms. The PEG2000-DSPE NMs (PEG2000-DSPE), P123 and PEG2000-DSPE mixed NMs (P123-PEG2000-DSPE), Dox-loaded PEG2000-DSPE NMs (PEG2000-DSPE (Dox)), and Dox-loaded Pluronic P123 and PEG2000-DSPE mixed NMs (P123-PEG2000-DSPE (Dox)) were prepared, and then the morphologies and the size distribution of PEG2000-DSPE (Dox) and P123-PEG2000-DSPE (Dox) were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS), respectively.

Identifiants

DOI: 10.18632/aging.103138 PMID: 32396524 PMC: PMC7244042
pubmed: 32396524
pii: 103138
doi: 10.18632/aging.103138
pmc: PMC7244042
doi:

Substances chimiques

Antibiotics, Antineoplastic 0
Micelles 0
pluronic block copolymer P123 2E9U4Y94DB
Doxorubicin 80168379AG
Poloxalene 9003-11-6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8289-8300

Références

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Auteurs

Xiaoyu Zhang (X)

Department of Thyroid and Breast III, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

Weibin Chen (W)

Department of Radiology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei Province, China.

Jie Bai (J)

Department of Thyroid and Breast III, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

Lijun Jin (L)

Department of Thyroid and Breast III, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

Xiaoning Kang (X)

Department of Ultrasound II, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

Hui Zhang (H)

Department of Thyroid and Breast III, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

Zunyi Wang (Z)

Department of Thyroid and Breast III, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antibiotiques antinéoplasiques › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Préparations pharmaceutiques › Micelles › Pluronic P123 modified nano micelles loaded...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Poloxalène › Pluronic P123 modified nano micelles loaded...