Virulence-mediated infectiousness and activity trade-offs and their impact on transmission potential of influenza patients.
infectious diseases
influenza
trade-off
transmission
virulence
Journal
Proceedings. Biological sciences
ISSN: 1471-2954
Titre abrégé: Proc Biol Sci
Pays: England
ID NLM: 101245157
Informations de publication
Date de publication:
27 05 2020
27 05 2020
Historique:
entrez:
13
5
2020
pubmed:
13
5
2020
medline:
22
7
2020
Statut:
ppublish
Résumé
Communicable diseases are often virulent, i.e. they cause morbidity symptoms in those infected. While some symptoms may be transmission-enhancing, other symptoms are likely to reduce transmission potential. For human diseases, the reduction in transmission opportunities is commonly caused by reduced activity. There is limited data regarding the potential impact of virulence on transmission potential. We performed an exploratory data analysis of 324 influenza patients at a university health centre during the 2016/2017 influenza season. We classified symptoms as infectiousness-related or morbidity-related and calculated two scores. The scores were used to explore the relationship between infectiousness, morbidity (virulence), and activity level. We found a decrease in the activity level with increasing morbidity scores. There was no consistent pattern between an activity level and an infectiousness score. We also found a positive correlation between morbidity and infectiousness scores. Overall, we find that increasing virulence leads to increased infectiousness and reduced activity, suggesting a trade-off that can impact overall transmission potential. Our findings indicate that a reduction of systemic symptoms may increase host activity without reducing infectiousness. Therefore, interventions should target both systemic- and infectiousness-related symptoms to reduce overall transmission potential. Our findings can also inform simulation models that investigate the impact of different interventions on transmission.
Identifiants
pubmed: 32396798
doi: 10.1098/rspb.2020.0496
pmc: PMC7287351
doi:
Banques de données
Dryad
['10.5061/dryad.51c59zw4v']
figshare
['10.6084/m9.figshare.c.4954115']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20200496Subventions
Organisme : NIAID NIH HHS
ID : U19 AI117891
Pays : United States
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