Effect of Sodium Bicarbonate Mouth Wash on Salivary pH and Interleukin-1β Levels among Smokers.

 Smoking induces changes in salivary pH and inflammatory biomarker levels associated with oral diseases. This study examined the effect of alkaline oral rinse to modify this effect of smoking on salivary study parameters.  A double-blind randomized controlled trial (RCT) on systemically healthy smokers was conducted. A total of 78 smokers, aged 18 to 40 years, were enrolled as per exclusion/inclusion criteria. An alkaline mouthwash was provided to the intervention group and a placebo to control group. Salivary pH and inflammatory biomarker interleukin (IL)-1β levels were evaluated at baseline and at follow-up (14 ± 2 days).  Chi-squared test, independaent  Sixty eight salivary samples were analyzed. All study parameters of the study sample were statistically insignificant between both intervention and control groups at baseline. pH level was 6.56 ± 0.53 at baseline and 6.62 ± 0.45 at follow-up in the intervention group; respective values for control group were 6.70 ± 0.36 and 6.83 ± 0.44 and the changes were not significant (  This randomized trial indicated that sodium bicarbonate mouth rinse is effective in decreasing IL-1β levels and increasing salivary pH favorable for prevention of oral diseases.

Déclaration de conflit d'intérêts

S.A.H. conceptualized this study. The methodology was shaped by A.W., N.A., and S.A.H. M.F.I. and Z.K. validated the facts of this study, and S.A.H., S.A., F.M., and S.A.H.B. provided a formal analysis of the present study. S.A.H. did the investigation. Data curation was done by A.W. and N.A., and the original draft was prepared by S.A.H. and S.A. The review and editing of this article was done by S.A., Z.K., M.F.I., and S.A.H. B. Finally, A.W. and N.A. supervised the entire research work and N.A., A.W., and M.F.I. conducted the project administration.None declared.