Vascular Drug Delivery Using Carrier Red Blood Cells: Focus on RBC Surface Loading and Pharmacokinetics.
drug delivery
pharmacokinetics
red blood cells
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
09 May 2020
09 May 2020
Historique:
received:
15
04
2020
revised:
30
04
2020
accepted:
08
05
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
14
5
2020
Statut:
epublish
Résumé
Red blood cells (RBC) have great potential as drug delivery systems, capable of producing unprecedented changes in pharmacokinetics, pharmacodynamics, and immunogenicity. Despite this great potential and nearly 50 years of research, it is only recently that RBC-mediated drug delivery has begun to move out of the academic lab and into industrial drug development. RBC loading with drugs can be performed in several ways-either via encapsulation within the RBC or surface coupling, and either ex vivo or in vivo-depending on the intended application. In this review, we briefly summarize currently used technologies for RBC loading/coupling with an eye on how pharmacokinetics is impacted. Additionally, we provide a detailed description of key ADME (absorption, distribution, metabolism, elimination) changes that would be expected for RBC-associated drugs and address unique features of RBC pharmacokinetics. As thorough understanding of pharmacokinetics is critical in successful translation to the clinic, we expect that this review will provide a jumping off point for further investigations into this area.
Identifiants
pubmed: 32397513
pii: pharmaceutics12050440
doi: 10.3390/pharmaceutics12050440
pmc: PMC7284780
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL143806
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01HL121134-02
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL138269
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007775
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1R01HL143806-01
Pays : United States
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