Strigolactone Analogs Are Promising Antiviral Agents for the Treatment of Human Cytomegalovirus Infection.

antiviral activity apoptosis human cytomegalovirus strigolactone analogs

Journal

Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893

Informations de publication

Date de publication:
10 May 2020
Historique:
received: 31 03 2020
revised: 07 05 2020
accepted: 08 05 2020
entrez: 14 5 2020
pubmed: 14 5 2020
medline: 14 5 2020
Statut: epublish

Résumé

The human cytomegalovirus (HCMV) is a widespread pathogen and is associated with severe diseases in immunocompromised individuals. Moreover, HCMV infection is the most frequent cause of congenital malformation in developed countries. Although nucleoside analogs have been successfully employed against HCMV, their use is hampered by the occurrence of serious side effects. There is thus an urgent clinical need for less toxic, but highly effective, antiviral drugs. Strigolactones (SLs) are a novel class of plant hormones with a multifaceted activity. While their role in plant-related fields has been extensively explored, their effects on human cells and their potential applications in medicine are far from being fully exploited. In particular, their antiviral activity has never been investigated. In the present study, a panel of SL analogs has been assessed for antiviral activity against HCMV. We demonstrate that TH-EGO and EDOT-EGO significantly inhibit HCMV replication in vitro, impairing late protein expression. Moreover, we show that the SL-dependent induction of apoptosis in HCMV-infected cells is a contributing mechanism to SL antiviral properties. Overall, our results indicate that SLs may be a promising alternative to nucleoside analogs for the treatment of HCMV infections.

Identifiants

pubmed: 32397638
pii: microorganisms8050703
doi: 10.3390/microorganisms8050703
pmc: PMC7284764
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Università degli Studi di Torino
ID : Ricerca Locale
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN 2015W729WH
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN 2015RMNSTA

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Auteurs

Matteo Biolatti (M)

Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.

Marco Blangetti (M)

Department of Chemistry, University of Turin, 10125 Turin, Italy.

Giulia D'Arrigo (G)

Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.

Francesca Spyrakis (F)

Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy.

Paola Cappello (P)

Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy.

Camilla Albano (C)

Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.

Paolo Ravanini (P)

Laboratory Medicine Department, Laboratory of Molecular Virology, "Maggiore della Carità" Hospital, 28100 Novara, Italy.

Santo Landolfo (S)

Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.

Marco De Andrea (M)

Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Center for Translational Research on Autoimmune and Allergic Disease-CAAD, 28100 Novara, Italy.

Cristina Prandi (C)

Department of Chemistry, University of Turin, 10125 Turin, Italy.

Valentina Dell'Oste (V)

Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.

Classifications MeSH