Targeted Dendrimer-Coated Magnetic Nanoparticles for Selective Delivery of Therapeutics in Living Cells.
Animals
Antineoplastic Agents
/ pharmacology
Cell Line, Tumor
Cell Survival
/ drug effects
Dendrimers
/ chemistry
Doxorubicin
/ pharmacology
Drug Carriers
/ chemistry
Drug Delivery Systems
/ methods
Drug Liberation
/ radiation effects
Humans
Hydrogen-Ion Concentration
Magnetics
Magnetite Nanoparticles
/ chemistry
Mice
Microscopy, Electron, Transmission
NIH 3T3 Cells
Particle Size
dendrimers
magnetic nanoparticles
peptide aptamers
targeted drug delivery
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
10 May 2020
10 May 2020
Historique:
received:
07
04
2020
revised:
03
05
2020
accepted:
09
05
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
3
3
2021
Statut:
epublish
Résumé
Nanoparticles are widely used as theranostic agents for the treatment of various pathologies, including cancer. Among all, dendrimers-based nanoparticles represent a valid approach for drugs delivery, thanks to their controllable size and surface properties. Indeed, dendrimers can be easily loaded with different payloads and functionalized with targeting agents. Moreover, they can be used in combination with other materials such as metal nanoparticles for combinatorial therapies. Here, we present the formulation of an innovative nanostructured hybrid system composed by a metallic core and a dendrimers-based coating that is able to deliver doxorubicin specifically to cancer cells through a targeting agent. Its dual nature allows us to transport nanoparticles to our site of interest through the magnetic field and specifically increase internalization by exploiting the T7 targeting peptide. Our system can release the drug in a controlled pH-dependent way, causing more than 50% of cell death in a pancreatic cancer cell line. Finally, we show how the system was internalized inside cancer cells, highlighting a peculiar disassembly of the nanostructure at the cell surface. Indeed, only the dendrimeric portion is internalized, while the metal core remains outside. Thanks to these features, our nanosystem can be exploited for a multistage magnetic vector.
Identifiants
pubmed: 32397665
pii: molecules25092252
doi: 10.3390/molecules25092252
pmc: PMC7249066
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Dendrimers
0
Drug Carriers
0
Magnetite Nanoparticles
0
Doxorubicin
80168379AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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