Neuroprotective Activity of
Alzheimer Disease
/ drug therapy
Amyloid Precursor Protein Secretases
/ adverse effects
Amyloid beta-Peptides
/ metabolism
Apoptosis
/ drug effects
Cell Line
Humans
Hydrogen Peroxide
/ adverse effects
MAP Kinase Kinase Kinase 5
/ metabolism
MAP Kinase Signaling System
/ drug effects
Mentha
/ chemistry
Neuroprotective Agents
Oxidative Stress
/ drug effects
Phytotherapy
Plant Extracts
/ pharmacology
Signal Transduction
bcl-2-Associated X Protein
/ metabolism
bcl-X Protein
/ metabolism
Alzheimer’s disease
Bax
Lamiaceae
amyloid β
caspase
mint
oxidative stress
β-secretase
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 May 2020
10 May 2020
Historique:
received:
18
04
2020
revised:
02
05
2020
accepted:
06
05
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with an unclear cause. It appears that multiple factors participate in the process of neuronal damage including oxidative stress and accumulation of the protein amyloid β (Aβ) in the brain. The search for a treatment for this disorder is essential as current medications are limited to alleviating symptoms and palliative effects. The aim of this study is to investigate the effects of mint extracts on selected mechanisms implicated in the development of AD. To enable a thorough investigation of mechanisms, including effects on β-secretase (the enzyme that leads to the formation of Aβ), on Aβ aggregation, and on oxidative stress and apoptosis pathways, a neuronal cell model, SH-SY5Y cells, was selected. Six
Identifiants
pubmed: 32397683
pii: nu12051366
doi: 10.3390/nu12051366
pmc: PMC7285141
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
BCL2L1 protein, human
0
Neuroprotective Agents
0
Plant Extracts
0
bcl-2-Associated X Protein
0
bcl-X Protein
0
Hydrogen Peroxide
BBX060AN9V
MAP Kinase Kinase Kinase 5
EC 2.7.11.25
MAP3K5 protein, human
EC 2.7.11.25
Amyloid Precursor Protein Secretases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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