SARS-CoV-2 Inflammatory Syndrome. Clinical Features and Rationale for Immunological Treatment.
COVID-19
SARS-CoV-2
acute respiratory syndrome
anti-cytokine antibodies
human immunoglobulin for intravenous use
immune system targeting in COVID-19
inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 May 2020
10 May 2020
Historique:
received:
23
04
2020
revised:
06
05
2020
accepted:
07
05
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
15
5
2020
Statut:
epublish
Résumé
The current pandemic coronavirus, SARS-CoV-2, is a global health emergency because of its highly contagious nature, the great number of patients requiring intensive care therapy, and the high fatality rate. In the absence of specific antiviral drugs, passive prophylaxis, or a vaccine, the treatment aim in these patients is to prevent the potent virus-induced inflammatory stimuli from leading to the acute respiratory distress syndrome (ARDS), which has a severe prognosis. Here, the mechanism of action and the rationale for employing immunological strategies, which range from traditional chemically synthesized drugs, anti-cytokine antibodies, human immunoglobulin for intravenous use, to vaccines, are reviewed.
Identifiants
pubmed: 32397684
pii: ijms21093377
doi: 10.3390/ijms21093377
pmc: PMC7247005
pii:
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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