Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells.

AMP-Activated Protein Kinases / immunology CD2 Antigens / immunology Humans Phosphoproteins / immunology Phosphorylation / immunology Proteomics Secretory Vesicles / immunology Signal Transduction / immunology T-Lymphocytes, Cytotoxic / immunology

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
12 05 2020
Historique:
entrez: 14 5 2020
pubmed: 14 5 2020
medline: 3 11 2021
Statut: epublish

Résumé

Understanding the costimulatory signaling that enhances the activity of cytotoxic T cells (CTLs) could identify potential targets for immunotherapy. Here, we report that CD2 costimulation plays a critical role in target cell killing by freshly isolated human CD8

Identifiants

DOI: 10.1126/scisignal.aaz1965 PMID: 32398348
pubmed: 32398348
pii: 13/631/eaaz1965
doi: 10.1126/scisignal.aaz1965
pii:
doi:

Substances chimiques

CD2 Antigens 0
Phosphoproteins 0
AMP-Activated Protein Kinases EC 2.7.11.31

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
ID : 200844/Z/16/Z
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Vanessa Zurli (V)

Department of Life Sciences, University of Siena, via Aldo Moro 2, Siena 53100, Italy.
ORCID: 0000-0001-8069-9242

Tommaso Montecchi (T)

Department of Life Sciences, University of Siena, via Aldo Moro 2, Siena 53100, Italy.

Raphael Heilig (R)

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
ORCID: 0000-0002-4860-3746

Isabel Poschke (I)

Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
ORCID: 0000-0002-4387-5566

Michael Volkmar (M)

Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
ORCID: 0000-0001-5970-1053

Giuliana Wimmer (G)

Department of Life Sciences, University of Siena, via Aldo Moro 2, Siena 53100, Italy.

Gioia Boncompagni (G)

Department of Life Sciences, University of Siena, via Aldo Moro 2, Siena 53100, Italy.

Gabriele Turacchio (G)

Institute of Biochemistry and Cell Biology, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy.

Mario Milco D'Elios (MM)

Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, Florence 50134, Italy.

Giuseppe Campoccia (G)

Department of Immune Hematology and Transfusion Medicine, University Hospital of Siena, viale Bracci 16, Siena 53100, Italy.

Nicoletta Resta (N)

Medical Genetics Unit, Department of Biomedical Sciences and Human Oncology, University of Bari, Policlinico Hospital, Piazza Giulio Cesare 11, Bari 70124, Italy.

Rienk Offringa (R)

Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
Department of Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.
ORCID: 0000-0001-6310-1026

Roman Fischer (R)

Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
ORCID: 0000-0002-9715-5951

Oreste Acuto (O)

Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

Cosima Tatiana Baldari (CT)

Department of Life Sciences, University of Siena, via Aldo Moro 2, Siena 53100, Italy. cosima.baldari@unisi.it a.kabanova@toscanalifesciences.org.
ORCID: 0000-0002-4414-6744

Anna Kabanova (A)

Department of Life Sciences, University of Siena, via Aldo Moro 2, Siena 53100, Italy. cosima.baldari@unisi.it a.kabanova@toscanalifesciences.org.
ORCID: 0000-0002-2077-472X

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › AMP-Activated Protein Kinases › Phosphoproteomics of CD2 signaling reveals...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD2 › Phosphoproteomics of CD2 signaling reveals...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Phosphoproteomics of CD2 signaling reveals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Phosphoproteomics of CD2 signaling reveals...
questionsmedicales.fr › Métabolisme › Phosphorylation › Phosphoproteomics of CD2 signaling reveals...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Phosphoproteomics of CD2 signaling reveals...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules de sécrétion › Phosphoproteomics of CD2 signaling reveals...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Phosphoproteomics of CD2 signaling reveals...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T cytotoxiques › Phosphoproteomics of CD2 signaling reveals...