Tamoxifen Exposure during Pregnancy: A Systematic Review and Three More Cases.

Breast cancer Breast carcinoma Pregnancy Tamoxifen Teratogenic effects

Journal

Breast care (Basel, Switzerland)
ISSN: 1661-3791
Titre abrégé: Breast Care (Basel)
Pays: Switzerland
ID NLM: 101254060

Informations de publication

Date de publication:
Apr 2020
Historique:
received: 06 05 2019
accepted: 13 06 2019
entrez: 14 5 2020
pubmed: 14 5 2020
medline: 14 5 2020
Statut: ppublish

Résumé

Tamoxifen is frequently used as adjuvant treatment in premenopausal patients with hormone receptor-positive early breast cancer. According to guidelines, the use of nonhormonal barrier contraception is recommended during tamoxifen treatment and up to 3 months after its interruption prior to attempting conception. Nevertheless, when conception occurs inadvertently during tamoxifen treatment, the effects on the fetus and on the course of pregnancy are still not completely known. Here, we report 3 cases of young women who accidentally became pregnant while taking tamoxifen and perform a systematic review of the literature to provide more elements for better and clear multidisciplinary counselling of women facing this challenging situation.

Identifiants

pubmed: 32398983
doi: 10.1159/000501473
pii: brc-0015-0148
pmc: PMC7204783
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

148-156

Informations de copyright

Copyright © 2019 by S. Karger AG, Basel.

Déclaration de conflit d'intérêts

A. Brunello served as a consultant for Roche and Eli Lilly, and she is part of the advisory board for Eisai and for Eli Lilly; L. Del Mastro received honoraria from Takeda and personal fees from Ipsen and Takeda outside the submitted work; M. Lambertini served as a consultant for Teva, and he received honoraria from Theramex outside the submitted work; F.A. Peccatori received honoraria from Roche, AstraZeneca, Clovis, Takeda, and Ipsen outside the submitted work; the other authors do not have any financial disclosure to declare.

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Auteurs

Barbara Buonomo (B)

Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.
Fertility and Procreation Unit, Division of Gynecologic Oncology, European Institute of Oncology IRCCS, Milan, Italy.

Antonella Brunello (A)

Medical Oncology 1 Unit, Department of Oncology, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy.

Stefania Noli (S)

Fertility and Procreation Unit, Division of Gynecologic Oncology, European Institute of Oncology IRCCS, Milan, Italy.
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.

Loredana Miglietta (L)

U.O.C. Oncologia Medica 2, Department of Medical Oncology, Ospedale Policlinico San Martino, Genoa, Italy.

Lucia Del Mastro (L)

S.S. Sviluppo Terapie Innovative, Department of Medical Oncology, Ospedale Policlinico San Martino, Genoa, Italy.
Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genoa, Genoa, Italy.

Matteo Lambertini (M)

Department of Internal Medicine and Medical Specialties (DIMI), School of Medicine, University of Genoa, Genoa, Italy.
Clinica di Oncologia Medica, Department of Medical Oncology, Ospedale Policlinico San Martino - IST, Genoa, Italy.

Fedro Alessandro Peccatori (FA)

Fertility and Procreation Unit, Division of Gynecologic Oncology, European Institute of Oncology IRCCS, Milan, Italy.

Classifications MeSH