Identification of RAG-like transposons in protostomes suggests their ancient bilaterian origin.

Adaptive immunity Evolution RAG Recombination activating genes Transposon Transposon molecular domestication

Journal

Mobile DNA
ISSN: 1759-8753
Titre abrégé: Mob DNA
Pays: England
ID NLM: 101519891

Informations de publication

Date de publication:
2020
Historique:
received: 18 12 2019
accepted: 14 04 2020
entrez: 14 5 2020
pubmed: 14 5 2020
medline: 14 5 2020
Statut: epublish

Résumé

V(D) J recombination is essential for adaptive immunity in jawed vertebrates and is initiated by the RAG1-RAG2 endonuclease. The We have identified numerous Active

Sections du résumé

BACKGROUND BACKGROUND
V(D) J recombination is essential for adaptive immunity in jawed vertebrates and is initiated by the RAG1-RAG2 endonuclease. The
RESULTS RESULTS
We have identified numerous
CONCLUSIONS CONCLUSIONS
Active

Identifiants

pubmed: 32399063
doi: 10.1186/s13100-020-00214-y
pii: 214
pmc: PMC7204232
doi:

Types de publication

Journal Article

Langues

eng

Pagination

17

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI137079
Pays : United States

Informations de copyright

© The Author(s) 2020.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare that they have no competing interest.

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Auteurs

Eliza C Martin (EC)

1Department of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, 060031 Bucharest, Romania.

Célia Vicari (C)

2Evolutionary biology team, Aix Marseille Université IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Louis Tsakou-Ngouafo (L)

2Evolutionary biology team, Aix Marseille Université IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Pierre Pontarotti (P)

2Evolutionary biology team, Aix Marseille Université IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France.
SNC5039 CNRS, 19-21 Boulevard Jean Moulin, 13005 Marseille, France.

Andrei J Petrescu (AJ)

1Department of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, 060031 Bucharest, Romania.

David G Schatz (DG)

4Department of Immunobiology, Yale School of Medicine, 300 Cedar Street, Box 208011, New Haven, CT 06520-8011 USA.

Classifications MeSH