Genome-Wide Association Study of Sleep Disturbances in Depressive Disorders.
Depression
Genetics
Genome-wide association study
Sleep disturbances
Journal
Molecular neuropsychiatry
ISSN: 2296-9209
Titre abrégé: Mol Neuropsychiatry
Pays: Switzerland
ID NLM: 101649121
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
19
12
2019
accepted:
21
12
2019
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
14
5
2020
Statut:
ppublish
Résumé
Sleep disturbance affects about 75% of depressed individuals and is associated with poorer patient outcomes. The genetics in this field is an emerging area of research. Thus far, only core circadian genes have been examined in this context. We expanded on this by performing a genome-wide association study (GWAS) followed by a preplanned hypothesis-driven analysis with 27 genes associated with the biology of sleep. All participants were diagnosed by their referring physician, completed the Beck Depression Inventory (BDI), and the Udvalg for Kliniske Undersogelser Side Effect Rating Scale at baseline. Our phenotype consisted of replies to 3 questions from these questionnaires. From standard GWAS chip data, imputations were performed. Baseline total BDI scores (
Identifiants
pubmed: 32399468
doi: 10.1159/000505804
pii: mnp-0005-0034
pmc: PMC7206592
doi:
Types de publication
Journal Article
Langues
eng
Pagination
34-43Informations de copyright
Copyright © 2019 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
J.L.K. is a member of the Scientific Advisory Board of Myriad Genetics (unpaid) and has several patents pertaining to pharmacogenetic testing for psychiatric illnesses. All other authors have no conflicts of interest to declare.
Références
PLoS One. 2010 Feb 18;5(2):e9259
pubmed: 20174623
Nat Genet. 2012 May;44(5):526-31
pubmed: 22484627
Sleep. 2008 Apr;31(4):481-8
pubmed: 18457235
J Neurosci. 2001 Mar 1;21(5):1656-62
pubmed: 11222656
Sleep. 2013 Mar 01;36(3):431-46
pubmed: 23449886
Dialogues Clin Neurosci. 2008;10(3):329-36
pubmed: 18979946
Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):570-581
pubmed: 19693801
Nat Protoc. 2011 Feb;6(2):121-33
pubmed: 21293453
J Neurosci. 2009 May 13;29(19):6114-23
pubmed: 19439589
Circulation. 2001 Jan 16;103(2):196-200
pubmed: 11208676
J Psychiatr Res. 2018 Jan;96:265-272
pubmed: 29301639
Mol Psychiatry. 2013 Apr;18(4):497-511
pubmed: 22472876
Eur J Hum Genet. 2014 Sep;22(9):1124-30
pubmed: 24448550
Lancet. 2015 Aug 22;386(9995):743-800
pubmed: 26063472
Cell. 2008 Jul 25;134(2):317-28
pubmed: 18662546
Nat Genet. 2017 Feb;49(2):274-281
pubmed: 27992416
Nat Commun. 2013;4:2739
pubmed: 24253340
Nat Protoc. 2007;2(10):2492-501
pubmed: 17947991
Nat Genet. 2016 Sep;48(9):1031-6
pubmed: 27479909
J Biol Chem. 1999 Jan 29;274(5):2690-5
pubmed: 9915799
J Biol Chem. 2008 Jun 13;283(24):16885-94
pubmed: 18385133
Neuropsychopharmacology. 2010 May;35(6):1279-89
pubmed: 20072116
J Gen Physiol. 2017 Dec 4;149(12):1065-1089
pubmed: 29122978
Cell. 1999 Aug 6;98(3):365-76
pubmed: 10458611
Acta Psychiatr Scand Suppl. 1987;334:1-100
pubmed: 2887090
Nat Rev Genet. 2010 Jul;11(7):459-63
pubmed: 20548291
J Clin Psychiatry. 2012 Apr;73(4):478-85
pubmed: 22152403
Nat Genet. 2012 Dec;44(12):1355-9
pubmed: 23104006
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Neuron. 2006 May 4;50(3):465-77
pubmed: 16675400
Nat Protoc. 2010 Sep;5(9):1564-73
pubmed: 21085122
Pediatrics. 2006 Sep;118(3):1124-32
pubmed: 16951007
Am J Med Genet B Neuropsychiatr Genet. 2003 Aug 15;121B(1):35-8
pubmed: 12898572
Nord J Psychiatry. 2008;62(5):360-5
pubmed: 18752106
Biol Psychiatry. 2005 Nov 1;58(9):694-9
pubmed: 16018976
BMC Med. 2011 Jul 26;9:90
pubmed: 21791035
Nature. 2002 Aug 29;418(6901):935-41
pubmed: 12198538
Psychol Med. 1998 May;28(3):731-5
pubmed: 9626729
Am J Med Genet B Neuropsychiatr Genet. 2014 Apr;165B(3):254-60
pubmed: 24687905
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Am J Psychiatry. 1997 Apr;154(4):502-9
pubmed: 9090337
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Annu Rev Neurosci. 2000;23:713-42
pubmed: 10845079
J Biol Rhythms. 2004 Jun;19(3):248-57
pubmed: 15155011
Biomed Chromatogr. 2011 Jan;25(1-2):11-20
pubmed: 21204109
Front Genet. 2014 Dec 11;5:370
pubmed: 25566314
J Affect Disord. 1997 Feb;42(2-3):209-12
pubmed: 9105962
Curr Opin Neurobiol. 2013 Oct;23(5):888-94
pubmed: 23618559
Nat Methods. 2011 Dec 04;9(2):179-81
pubmed: 22138821
Mol Biol Rep. 2015 Jan;42(1):277-88
pubmed: 25258123
Handb Exp Pharmacol. 2012;(207):23-41
pubmed: 22566219
JAMA. 2003 Jun 18;289(23):3095-105
pubmed: 12813115