Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial.

Beta cells C-peptide Interleukin-2 Treg adolescents aldesleukin children immunotherapy type 1 diabetes

Journal

Wellcome open research
ISSN: 2398-502X
Titre abrégé: Wellcome Open Res
Pays: England
ID NLM: 101696457

Informations de publication

Date de publication:
2020
Historique:
accepted: 10 03 2020
entrez: 14 5 2020
pubmed: 14 5 2020
medline: 14 5 2020
Statut: epublish

Résumé

Type 1 diabetes is a common autoimmune disease due to destruction of pancreatic β cells, resulting in lifelong need for insulin. Evidence suggest that maintaining residual β-cell function can improve glucose control and reduce risk of hypoglycaemia and vascular complications. Non-clinical, preclinical and some preliminary clinical data suggest that low-dose interleukin-2 (IL-2) therapy could block pancreatic β cells destruction by increasing the number of functional regulatory T cells (Tregs) that inhibit islet-specific autoreactive effector T cells (Teffs). However, there is lack of data on the effect of low-dose IL-2 in newly diagnosed children and adolescents with T1D as well as lack of specific data on its potential effect on β-cell function. The '

Identifiants

pubmed: 32399500
doi: 10.12688/wellcomeopenres.15697.1
pmc: PMC7194454
doi:

Banques de données

figshare
['10.6084/m9.figshare.11932491.v1']

Types de publication

Journal Article

Langues

eng

Pagination

49

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright: © 2020 Marcovecchio ML et al.

Déclaration de conflit d'intérêts

No competing interests were disclosed.

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Auteurs

M Loredana Marcovecchio (ML)

Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK.

Linda S Wicker (LS)

JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK.

David B Dunger (DB)

Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK.
Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0QQ, UK.

Susan J Dutton (SJ)

Oxford Clinical Trials Research Unit, Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

Sylwia Kopijasz (S)

JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK.

Claire Scudder (C)

JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK.

John A Todd (JA)

JDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK.

Paul R V Johnson (PRV)

Islet Transplant Research Group, Nuffield Department of Surgical Sciences, Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, OX3 9DU, UK.

Classifications MeSH