Combined Effects of
Food hypersensitivity
Lactobacillus rhamnosus
immunotherapy
probiotics, IgE
Journal
Allergy, asthma & immunology research
ISSN: 2092-7355
Titre abrégé: Allergy Asthma Immunol Res
Pays: Korea (South)
ID NLM: 101518382
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
23
07
2019
revised:
17
01
2020
accepted:
04
02
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
14
5
2020
Statut:
ppublish
Résumé
Recent clinical trials have successfully used oral immunotherapy (OIT) to treat food allergies. Probiotics have immunomodulatory effects by balancing Th1/Th2 immunity and enhancing regulatory T-cell activity. In this study, we analyzed the effects of OIT, probiotics alone, and probiotics administered simultaneously with OIT in a mouse model of egg allergy. C3H/HeJ mice were sensitized by intragastric administration of ovomucoid (OM) with cholera toxin. For the OIT regime, increasing doses of OM were administered orally to sensitized mice. The severity of anaphylaxis decreased in all treatment groups. Simultaneous administration of Lcr35 and OIT decreased the severity of anaphylaxis compared to controls and the OIT group. The protective effects were sustained 2 weeks after ceasing treatment in all treatment groups. A significant decrease in OM-specific IgA, IgG1, and IgG2a levels was observed in both the OIT and OIT plus Lcr35 groups. However, a significant decrease in the OM-specific IgE level was observed only in OIT plus Lcr35 treated mice and was sustained 2 weeks after ceasing treatment. Mucin amounts in the small intestine decreased after OIT, OIT plus Lcr35, and Lcr35 treatment with the lowest in the OIT plus Lcr35 group. Lcr35 treatment during OIT had some synergic effect for protection against anaphylaxis in a mice model of egg allergy. These findings should be confirmed in future animal studies including more detailed immunological profiles and human studies.
Identifiants
pubmed: 32400134
pii: 12.701
doi: 10.4168/aair.2020.12.4.701
pmc: PMC7225004
doi:
Types de publication
Journal Article
Langues
eng
Pagination
701-711Subventions
Organisme : Soonchunhyang University
Pays : Korea
Informations de copyright
Copyright © 2020 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
Déclaration de conflit d'intérêts
There are no financial or other issues that might lead to conflict of interest.
Références
J Allergy Clin Immunol. 2013 Jan;131(1):14-22
pubmed: 23265693
Allergy Asthma Immunol Res. 2017 Sep;9(5):423-430
pubmed: 28677356
J Allergy Clin Immunol. 1999 May;103(5 Pt 1):717-28
pubmed: 10329801
Allergy Asthma Immunol Res. 2013 Jan;5(1):3-15
pubmed: 23277873
J Allergy Clin Immunol. 2014 Dec;134(6):1310-1317.e6
pubmed: 25042981
Cochrane Database Syst Rev. 2012 Sep 12;(9):CD009014
pubmed: 22972130
Curr Opin Allergy Clin Immunol. 2004 Aug;4(4):313-8
pubmed: 15238798
J Allergy Clin Immunol. 2007 Jan;119(1):199-205
pubmed: 17208602
Allergy Asthma Immunol Res. 2017 Mar;9(2):107-115
pubmed: 28102055
Allergy. 2011 Apr;66(4):499-508
pubmed: 21058959
J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):206-14
pubmed: 9949309
Allergy Asthma Immunol Res. 2014 Mar;6(2):131-6
pubmed: 24587949
FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):259-67
pubmed: 15963706
Lancet Child Adolesc Health. 2017 Oct;1(2):97-105
pubmed: 30169215
J Allergy Clin Immunol. 2002 Aug;110(2):304-9
pubmed: 12170273
Vaccine. 2010 Apr 9;28(17):2986-92
pubmed: 20175969
Allergy Asthma Immunol Res. 2019 Jul;11(4):498-507
pubmed: 31172718
Pediatrics. 2009 Dec;124(6):1549-55
pubmed: 19917585
Allergy. 2016 Nov;71(11):1552-1560
pubmed: 27015954
J Allergy Clin Immunol. 2008 Jun;121(6):1448-54
pubmed: 18436293
J Microbiol Biotechnol. 2018 Jan 28;28(1):65-76
pubmed: 29121702
Curr Opin Immunol. 2016 Oct;42:119-123
pubmed: 27745972
Immunol Allergy Clin North Am. 2016 Feb;36(1):87-102
pubmed: 26617229
Thorax. 2007 Jan;62(1):91-6
pubmed: 16950836
Allergy Asthma Immunol Res. 2018 May;10(3):189-206
pubmed: 29676066
J Allergy Clin Immunol. 2010 Aug;126(2):375-83
pubmed: 20624641
Allergy Asthma Immunol Res. 2018 Nov;10(6):575-590
pubmed: 30306743
Int Arch Allergy Immunol. 2010;151(2):107-17
pubmed: 19752564
Mol Nutr Food Res. 2013 Dec;57(12):2233-44
pubmed: 23943347
Int Arch Allergy Immunol. 2012;158(1):35-42
pubmed: 22205338
J Allergy Clin Immunol. 2012 Jun;129(6):1579-1587.e1
pubmed: 22554705
Allergy Asthma Immunol Res. 2017 Jan;9(1):35-42
pubmed: 27826960
J Allergy Clin Immunol. 2015 Mar;135(3):737-44.e8
pubmed: 25592987
Pediatr Allergy Immunol. 2013 Sep;24(6):512-20
pubmed: 23905867
N Engl J Med. 2012 Jul 19;367(3):233-43
pubmed: 22808958
Pediatr Allergy Immunol. 2016 May;27(3):276-82
pubmed: 26764899