CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation.

Animals Autophagy / physiology Dendritic Cells / metabolism Encephalomyelitis, Autoimmune, Experimental / immunology Inflammation / metabolism Lymphocyte Activation / immunology Macrophages / metabolism Myelin-Oligodendrocyte Glycoprotein / immunology NADPH Oxidase 2 / metabolism Phagocytosis / immunology T-Lymphocytes / metabolism
Antigen presentation CYBB/NOX2 LC3-associated phagocytosis autophagy dendritic cells experimental autoimmune encephalomyelitis multiple sclerosis

Journal

Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188

Informations de publication

Date de publication:
05 2021
Historique:
pubmed: 14 5 2020
medline: 15 12 2021
entrez: 14 5 2020
Statut: ppublish

Résumé

Whereas central nervous system (CNS) homeostasis is highly dependent on tissue surveillance by immune cells, dysregulated entry of leukocytes during autoimmune neuroinflammation causes severe immunopathology and neurological deficits. To invade the CNS parenchyma, encephalitogenic T helper (T

Identifiants

DOI: 10.1080/15548627.2020.1756678 PMID: 32401602 PMC: PMC8143233
pubmed: 32401602
doi: 10.1080/15548627.2020.1756678
pmc: PMC8143233
doi:

Substances chimiques

Myelin-Oligodendrocyte Glycoprotein 0
Cybb protein, mouse EC 1.6.3.-
NADPH Oxidase 2 EC 1.6.3.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1244-1258

Subventions

Organisme : British Heart Foundation
ID : CH/1999001/11735
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/11/30384
Pays : United Kingdom

Références

Science. 2005 Mar 11;307(5715):1630-4
pubmed: 15761154
J Exp Med. 2002 Aug 19;196(4):529-40
pubmed: 12186844
Circulation. 2017 May 30;135(22):2163-2177
pubmed: 28298457
J Cell Biol. 2013 Dec 9;203(5):757-66
pubmed: 24322427
Nat Cell Biol. 2015 Jul;17(7):893-906
pubmed: 26098576
J Exp Med. 2014 Jul 28;211(8):1533-49
pubmed: 25002752
Front Cell Neurosci. 2017 Jan 10;10:301
pubmed: 28119569
Sci Immunol. 2019 Jan 25;4(31):
pubmed: 30679199
Science. 2019 Jan 25;363(6425):
pubmed: 30679343
Brain. 2012 Mar;135(Pt 3):886-99
pubmed: 22366799
J Immunol. 2014 Jun 1;192(11):4989-5001
pubmed: 24778444
J Biol Chem. 2014 Sep 19;289(38):26525-26532
pubmed: 25077962
Eur J Immunol. 2018 Aug;48(8):1308-1318
pubmed: 29697861
J Exp Med. 2012 Jun 4;209(6):1135-52
pubmed: 22615127
J Exp Med. 2016 Apr 4;213(4):517-34
pubmed: 27001748
Semin Immunopathol. 2010 Dec;32(4):415-30
pubmed: 20803017
Nat Cell Biol. 2011 Oct 16;13(11):1335-43
pubmed: 22002674
J Alzheimers Dis. 2010;20 Suppl 2:S453-73
pubmed: 20463398
Immunity. 2015 Sep 15;43(3):502-14
pubmed: 26341401
Cell. 2019 Jul 25;178(3):536-551.e14
pubmed: 31257024
Science. 2003 Feb 28;299(5611):1400-3
pubmed: 12610307
Nat Rev Neurol. 2019 Dec;15(12):704-717
pubmed: 31527807
Nature. 2016 May 5;533(7601):115-9
pubmed: 27096368
Cell Rep. 2017 Jul 5;20(1):201-210
pubmed: 28683313
EMBO J. 2018 Feb 15;37(4):
pubmed: 29317426
Brain. 2009 Sep;132(Pt 9):2487-500
pubmed: 19531531
Mitochondrion. 2010 Aug;10(5):411-8
pubmed: 20573557
J Exp Med. 2012 Jun 4;209(6):1153-65
pubmed: 22615130
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6226-31
pubmed: 19339495
Immunity. 2012 Aug 24;37(2):264-75
pubmed: 22902234
Immunity. 2009 Apr 17;30(4):544-55
pubmed: 19328020
J Neuroinflammation. 2010 Jul 26;7:41
pubmed: 20659322
J Biol Chem. 2012 Oct 5;287(41):34149-56
pubmed: 22902620
Proc Natl Acad Sci U S A. 2003 May 13;100(10):6145-50
pubmed: 12721370
Immunity. 2018 Feb 20;48(2):380-395.e6
pubmed: 29426702
J Clin Invest. 2018 Dec 3;128(12):5322-5334
pubmed: 30226829
Cell. 2006 Jul 14;126(1):205-18
pubmed: 16839887
Eur J Immunol. 2012 Oct;42(10):2555-63
pubmed: 22806332
Nat Immunol. 2017 Mar 22;18(4):385-392
pubmed: 28323268
J Clin Invest. 2015 Apr;125(4):1371-8
pubmed: 25831441
Nat Med. 2011 Apr;17(4):495-9
pubmed: 21441916
Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11228-E11237
pubmed: 29233943
Cell. 2018 Oct 4;175(2):429-441.e16
pubmed: 30245008
Nature. 2009 Nov 5;462(7269):94-8
pubmed: 19829296

Auteurs

Christian W Keller (CW)

Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Laboratory of Neuroinflammation, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0003-2276-0003

Monika B Kotur (MB)

Laboratory of Neuroinflammation, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

Sarah Mundt (S)

Laboratory of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0003-2169-2109

Nikolaos Dokalis (N)

Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Faculty of Biology, University of Freiburg, Freiburg, Germany.

Laure-Anne Ligeon (LA)

Laboratory of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

Ajay M Shah (AM)

King's College London British Heart Foundation Centre of Excellence, School of Cardiovascular Medicine & Sciences, London, UK.

Marco Prinz (M)

Institute of Neuropathology, University of Freiburg; Signalling Research Centres BIOSS and CIBSS, Center for Basics in NeuroModulation (Neuromodulbasics), University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-0349-1955

Burkhard Becher (B)

Laboratory of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

Christian Münz (C)

Laboratory of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

Jan D Lünemann (JD)

Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Laboratory of Neuroinflammation, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0002-3007-708X

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

Within-subject variation of C-reactive protein and high-sensitivity C-reactive protein: A systematic review and meta-analysis.

Alex Gough, Alice Sitch, Erica Ferris et al.
1.00
C-Reactive Protein Humans Biomarkers Inflammation

Prognostic value of the systemic immune-inflammation index in lung cancer patients receiving immune checkpoint inhibitors: A meta-analysis.

Yanhui Yang, Ji Li, Yi Wang et al.
1.00
Humans Immune Checkpoint Inhibitors Lung Neoplasms Prognosis Inflammation

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Glycoprotéine MOG › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › NADPH Oxidase 2 › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Phénomènes du système immunitaire › Phagocytose › CYBB/NOX2 in conventional DCs controls T cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › CYBB/NOX2 in conventional DCs controls T cell...