Indocyanine Green Fluorescence Imaging to Predict Graft Survival After Orthotopic Liver Transplantation: A Pilot Study.
Journal
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
ISSN: 1527-6473
Titre abrégé: Liver Transpl
Pays: United States
ID NLM: 100909185
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
15
01
2020
revised:
23
03
2020
accepted:
25
04
2020
pubmed:
14
5
2020
medline:
19
3
2021
entrez:
14
5
2020
Statut:
ppublish
Résumé
The incidence of primary nonfunction (PNF) after liver transplantation (LT) remains a major concern with the increasing use of marginal grafts. Indocyanine green (ICG) fluorescence is an imaging technique used in hepatobiliary surgery and LT. Because few early predictors are available, we aimed to quantify in real time the fluorescence of grafts during LT to predict 3-month survival. After graft revascularization, ICG was intravenously injected, and then the fluorescence of the graft was captured with a near infrared camera and postoperatively quantified. A multiparametric modeling of the parenchymal fluorescence intensity (FI) curve was proposed, and a predictive model of graft survival was tested. Between July 2017 and May 2019, 76 LTs were performed, among which 6 recipients underwent retransplantation. No adverse effects of ICG injection were observed. The parameter a
Substances chimiques
Indocyanine Green
IX6J1063HV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1263-1274Informations de copyright
Copyright © 2020 by the American Association for the Study of Liver Diseases.
Références
Giretti G, Barbier L, Bucur P, Marques F, Perarnau JM, Ferrandière M, et al. Recipient selection for optimal utilization of discarded grafts in liver transplantation. Transplantation 2018;102:775-782.
Nemes B, Gámán G, Polak WG, Gelley F, Hara T, Ono S, et al. Extended-criteria donors in liver transplantation Part II: reviewing the impact of extended-criteria donors on the complications and outcomes of liver transplantation. Expert Rev Gastroenterol Hepatol 2016;10:841-859.
Barshes NR, Horwitz IB, Franzini L, Vierling JM, Goss JA. Waitlist mortality decreases with increased use of extended criteria donor liver grafts at adult liver transplant centers. Am J Transplant 2007;7:1265-1270.
Olthoff KM, Kulik L, Samstein B, Kaminski M, Abecassis M, Emond J, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl 2010;16:943-949.
Golse N, Guglielmo N, El Metni A, Frosio F, Cosse C, Naili S, et al. Arterial lactate concentration at the end of liver transplantation is an early predictor of primary graft dysfunction. Ann Surg 2019;270:131-138.
Chen XB, Xu MQ. Primary graft dysfunction after liver transplantation. Hepatobiliary Pancreat Dis Int 2014;13:125-137.
Bolondi G, Mocchegiani F, Montalti R, Nicolini D, Vivarelli M, De Pietri L. Predictive factors of short term outcome after liver transplantation: a review. World J Gastroenterol 2016;22:5936-5949.
Figueroa R, Golse N, Alvarez FA, Ciacio O, Pittau G, Sa Cunha A, et al. Indocyanine green fluorescence imaging to evaluate graft perfusion during liver transplantation. HPB 2019;21:387-392.
Uemura T, Randall HB, Sanchez EQ, Ikegami T, Narasimhan G, McKenna GJ, et al. Liver retransplantation for primary nonfunction: analysis of a 20-year single-center experience. Liver Transpl 2007;13:227-233.
Lim C, Vibert E, Azoulay D, Salloum C, Ishizawa T, Yoshioka R, et al. Indocyanine green fluorescence imaging in the surgical management of liver cancers: current facts and future implications. J Visc Surg 2014;151:117-124.
Imamura H, Sano K, Sugawara Y, Kokudo N, Makuuchi M. Assessment of hepatic reserve for indication of hepatic resection: decision tree incorporating indocyanine green test. J Hepatobiliary Pancreat Surg 2005;12:16-22.
Kawaguchi Y, Akamatsu N, Ishizawa T, Kaneko J, Arita J, Sakamoto Y, et al. Evaluation of hepatic perfusion in the liver graft using fluorescence imaging with indocyanine green. Int J Surg Case Rep 2015;14:149-151.
Narasaki H, Noji T, Wada H, Ebihara Y, Tsuchikawa T, Okamura K, et al. Intraoperative real-time assessment of liver function with near-infrared fluorescence imaging. Eur Surg Res 2017;58:235-245.
Kawaguchi Y, Ishizawa T, Miyata Y, Yamashita S, Masuda K, Satou S, et al. Portal uptake function in veno-occlusive regions evaluated by real-time fluorescent imaging using indocyanine green. J Hepatol 2013;58:247-253.
Kawaguchi Y, Nomura Y, Nagai M, Koike D, Sakuraoka Y, Ishida T, et al. Liver transection using indocyanine green fluorescence imaging and hepatic vein clamping. Br J Surg 2017;104:898-906.
Bismuth H, Chiche L, Adam R, Castaing D, Diamond T, Dennison A. Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients. Ann Surg 1993;218:145-151.
Azoulay D, Bhangui P, Andreani P, Salloum C, Karam V, Hoti E, et al. Short- and long-term donor morbidity in right lobe living donor liver transplantation: 91 consecutive cases in a European Center. Am J Transplant 2011;11:101-110.
Azoulay D, Castaing D, Adam R, Savier E, Delvart V, Karam V, et al. Split-liver transplantation for two adult recipients: feasibility and long-term outcomes. Ann Surg 2001;233:565-574.
Azoulay D, Samuel D, Castaing D, Adam R, Adams D, Said G, et al. Domino liver transplants for metabolic disorders: experience with familial amyloidotic polyneuropathy. J Am Coll Surg 1999;189:584-593.
Gaffey MJ, Boyd JC, Traweek ST, Ali MA, Rezeig M, Caldwell SH, et al. Predictive value of intraoperative biopsies and liver function tests for preservation injury in orthotopic liver transplantation. Hepatology 1997;25:184-189.
Audebert C, Vignon-Clementel IE. Model and methods to assess hepatic function from indocyanine green fluorescence dynamical measurements of liver tissue. Eur J Pharm Sci 2018;115:304-319.
Detter C, Wipper S, Russ D, Iffland A, Burdorf L, Thein E, et al. Fluorescent cardiac imaging: a novel intraoperative method for quantitative assessment of myocardial perfusion during graded coronary artery stenosis. Circulation 2007;116:1007-1014.
Memeo R, Ciacio O, Pittau G, Cherqui D, Castaing D, Adam R, et al. Systematic computer tomographic scans 7 days after liver transplantation surgery can lower rates of repeat-transplantation due to arterial complications. Transplant Proc 2014;46:3536-3542.
Pokorny H, Gruenberger T, Soliman T, Rockenschaub S, Längle F, Steininger R. Organ survival after primary dysfunction of liver grafts in clinical orthotopic liver transplantation. Transpl Int 2000;13(suppl 1):S154-S157.
Nasralla D, Coussios CC, Mergental H, Akhtar MZ, Butler AJ, Ceresa CDL, et al. A randomized trial of normothermic preservation in liver transplantation. Nature 2018;557:50-56.
Levesque E, Saliba F, Benhamida S, Ichaï P, Azoulay D, Adam R, et al. Plasma disappearance rate of indocyanine green: a tool to evaluate early graft outcome after liver transplantation. Liver Transpl 2009;15:1358-1364.
Gomez Gavara C, Bhangui P, Salloum C, Osseis M, Esposito F, Moussallem T, et al. Ligation versus no ligation of spontaneous portosystemic shunts during liver transplantation: audit of a prospective series of 66 consecutive patients. Liver Transpl 2018;24:505-515.
de Graaf W, Häusler S, Heger M, van Ginhoven TM, van Cappellen G, Bennink RJ, et al. Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. J Hepatol 2011;54:738-745.