Animals
Epithelial Cells
/ metabolism
Glycosylation
Hexosyltransferases
/ metabolism
Interleukin-13
/ metabolism
Interleukin-13 Receptor alpha2 Subunit
/ metabolism
Lung
/ metabolism
Membrane Proteins
/ metabolism
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases
/ metabolism
Receptors, Interleukin-13
/ metabolism
Wnt Signaling Pathway
/ physiology
IL-13
IL-13 receptor α2
N-glycosylation
chitinase 3–like-1
oligosaccharyltransferase
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
pubmed:
14
5
2020
medline:
21
10
2020
entrez:
14
5
2020
Statut:
ppublish
Résumé
Chitinase 3-like-1 (Chi3l1) and IL-13 are both ligands of IL-13 receptor α2 (IL-13Rα2). The binding of the former activates mitogen-activated protein kinase, AKT, and Wnt/β-catenin signaling, and plays important roles in innate and adaptive immunity, cellular apoptosis, oxidative injury, allergic inflammation, tumor metastasis and wound healing, fibrosis, and repair in the lung. In contrast, the latter binding is largely a decoy event that diminishes the effects of IL-13. Here, we demonstrate that IL-13Rα2
Identifiants
pubmed: 32402213
doi: 10.1165/rcmb.2019-0446OC
pmc: PMC7462338
doi:
Substances chimiques
Interleukin-13
0
Interleukin-13 Receptor alpha2 Subunit
0
Membrane Proteins
0
Receptors, Interleukin-13
0
Hexosyltransferases
EC 2.4.1.-
Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
386-395Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL114501
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL115813
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL108638
Pays : United States
Commentaires et corrections
Type : CommentIn
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