Neural Correlates of Multisensory Detection Behavior: Comparison of Primary and Higher-Order Visual Cortex.
AL
V1
auditory
calcium imaging
crossmodal
detection
multisensory integration
perception
population coding
visual
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
12 05 2020
12 05 2020
Historique:
received:
20
06
2019
revised:
10
01
2020
accepted:
21
04
2020
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
21
5
2021
Statut:
ppublish
Résumé
We act upon stimuli in our surrounding environment by gathering the multisensory information they convey and by integrating this information to decide on a behavioral action. We hypothesized that the anterolateral secondary visual cortex (area AL) of the mouse brain may serve as a hub for sensorimotor transformation of audiovisual information. We imaged neuronal activity in primary visual cortex (V1) and AL of the mouse during a detection task using visual, auditory, and audiovisual stimuli. We found that AL neurons were more sensitive to weak uni- and multisensory stimuli compared to V1. Depending on contrast, different subsets of AL and V1 neurons showed cross-modal modulation of visual responses. During audiovisual stimulation, AL neurons showed stronger differentiation of behaviorally reported versus unreported stimuli compared to V1, whereas V1 showed this distinction during unisensory visual stimulation. Thus, neural population activity in area AL correlates more closely with multisensory detection behavior than V1.
Identifiants
pubmed: 32402272
pii: S2211-1247(20)30589-1
doi: 10.1016/j.celrep.2020.107636
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107636Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.