GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity.
Actins
/ metabolism
Brain
/ blood supply
Endothelium
/ drug effects
Growth Hormone-Releasing Hormone
/ antagonists & inhibitors
HeLa Cells
Humans
Hydrogen Peroxide
/ toxicity
Microvessels
/ pathology
Neuroprotective Agents
/ pharmacology
Sermorelin
/ analogs & derivatives
Tumor Suppressor Protein p53
/ metabolism
Journal
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
ISSN: 1439-4286
Titre abrégé: Horm Metab Res
Pays: Germany
ID NLM: 0177722
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
entrez:
14
5
2020
pubmed:
14
5
2020
medline:
27
2
2021
Statut:
ppublish
Résumé
Growth hormone releasing hormone is a hypothalamic neuropeptide, which regulates the release of growth hormone from the anterior pituitary gland. Growth hormone releasing hormone antagonists are anticancer agents, associated with strong anti-inflammatory activities. In the present study, we investigated the effects of the GHRH antagonist MIA-602 in the integrity of the brain microvascular endothelium in vitro. Our observations suggest that MIA-602 protects against the H
Substances chimiques
Actins
0
GHRH(1-29)NH2, (PhAc-Ada)(0)-Tyr(1), Arg(2), Fpa(5,6), Ala(8), Har(9), Tyr(Me)(10), His(11), Orn(12,) Abu(15), His(20), Orn(21), Nle(27), Arg(28), Har(29)-
0
Neuroprotective Agents
0
Tumor Suppressor Protein p53
0
Sermorelin
86168-78-7
Growth Hormone-Releasing Hormone
9034-39-3
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
336-339Subventions
Organisme : LEQSF(2019-22)-RD-A-26
ID : R & D, Research Competitiveness Subprogram (RCS) of the Louisiana Board of Regents through the Board of Regents Support Fund
Informations de copyright
© Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.