The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury.
hydroperoxide
inflammation
ionizing radiation
liver
sirtuin 3
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
11 May 2020
11 May 2020
Historique:
received:
11
04
2020
revised:
29
04
2020
accepted:
30
04
2020
entrez:
15
5
2020
pubmed:
15
5
2020
medline:
15
5
2020
Statut:
epublish
Résumé
In patients with abdominal region cancers, ionizing radiation (IR)-induced long-term liver injury is a major limiting factor in the use of radiotherapy. Previously, the major mitochondrial deacetylase, sirtuin 3 (SIRT3), has been implicated to play an important role in the development of acute liver injury after total body irradiation but no studies to date have examined the role of SIRT3 in liver's chronic response to radiation. In the current study, ten-month-old Sirt3
Identifiants
pubmed: 32403251
pii: antiox9050409
doi: 10.3390/antiox9050409
pmc: PMC7278565
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM109005
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM106999
Pays : United States
Organisme : Arkansas Science and Technology Authority Award
ID : AWD50506 15-B-19
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