Relevance of biomarkers across different neurodegenerative diseases.

Alzheimer Disease / diagnosis Amyloid beta-Peptides Biomarkers Disease Progression Humans Neurodegenerative Diseases / diagnosis tau Proteins
Alzheimer’s disease Amyloid Biomarkers Cerebrospinal fluid Magnetic resonance imaging Neurodegenerative diseases Neurofilament light chain Plasma biomarkers Positron emission tomography Tau

Journal

Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643

Informations de publication

Date de publication:
13 05 2020
Historique:
received: 08 11 2019
accepted: 16 03 2020
entrez: 15 5 2020
pubmed: 15 5 2020
medline: 25 6 2021
Statut: epublish

Résumé

The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and increasing use, appropriate implementation and interpretation are paramount. Various biomarkers feature nuanced differences in strengths, limitations, and biases that must be considered when investigating disease etiology and clinical utility. For example, neuropathological investigations of Alzheimer's disease pathogenesis can fall in disagreement with conclusions reached by biomarker-based investigations. Considering the varied strengths, limitations, and biases of different research methodologies and approaches may help harmonize disciplines within the neurodegenerative disease field. Along with separate review articles covering fluid and imaging biomarkers in this issue of Alzheimer's Research and Therapy, we present the result of a discussion from the 2019 Biomarkers in Neurodegenerative Diseases course at the University College London. Here, we discuss themes of biomarker use in neurodegenerative disease research, commenting on appropriate use, interpretation, and considerations for implementation across different neurodegenerative diseases. We also draw attention to areas where biomarker use can be combined with other disciplines to understand issues of pathophysiology and etiology underlying dementia. Lastly, we highlight novel modalities that have been proposed in the landscape of neurodegenerative disease research and care.

Sections du résumé

BACKGROUND
The panel of fluid- and imaging-based biomarkers available for neurodegenerative disease research is growing and has the potential to close important gaps in research and the clinic. With this growth and increasing use, appropriate implementation and interpretation are paramount. Various biomarkers feature nuanced differences in strengths, limitations, and biases that must be considered when investigating disease etiology and clinical utility. For example, neuropathological investigations of Alzheimer's disease pathogenesis can fall in disagreement with conclusions reached by biomarker-based investigations. Considering the varied strengths, limitations, and biases of different research methodologies and approaches may help harmonize disciplines within the neurodegenerative disease field.
PURPOSE OF REVIEW
Along with separate review articles covering fluid and imaging biomarkers in this issue of Alzheimer's Research and Therapy, we present the result of a discussion from the 2019 Biomarkers in Neurodegenerative Diseases course at the University College London. Here, we discuss themes of biomarker use in neurodegenerative disease research, commenting on appropriate use, interpretation, and considerations for implementation across different neurodegenerative diseases. We also draw attention to areas where biomarker use can be combined with other disciplines to understand issues of pathophysiology and etiology underlying dementia. Lastly, we highlight novel modalities that have been proposed in the landscape of neurodegenerative disease research and care.

Identifiants

DOI: 10.1186/s13195-020-00601-w PMID: 32404143 PMC: PMC7222479
pubmed: 32404143
doi: 10.1186/s13195-020-00601-w
pii: 10.1186/s13195-020-00601-w
pmc: PMC7222479
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

56

Subventions

Organisme : NIA NIH HHS
ID : K24 AG053435
Pays : United States
Organisme : NINDS NIH HHS
ID : U54 NS100717
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States

Commentaires et corrections

Type : ErratumIn

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Auteurs

Alexander J Ehrenberg (AJ)

Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. alexander.ehrenberg@ucsf.edu.
Department of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA. alexander.ehrenberg@ucsf.edu.
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA. alexander.ehrenberg@ucsf.edu.

Ayesha Khatun (A)

Dementia Research Centre, University College London Institute of Neurology, London, UK.

Emma Coomans (E)

Department of Radiology & Nuclear Medicine, Amsterdam UMC, location VUmc, Amsterdam Neuroscience, Amsterdam, The Netherlands.

Matthew J Betts (MJ)

German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany.

Federica Capraro (F)

The Francis Crick Institute, London, UK.
Department of Neuromuscular Diseases, University College London Queen Square Institute of Neurology, London, UK.

Elisabeth H Thijssen (EH)

Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, The Netherlands.

Konstantin Senkevich (K)

Petersburg Nuclear Physics Institute names by B.P. Konstantinov of National Research Center, Kurchatov Institute, St. Petersburg, Russia.
First Pavlov State Medical University of St. Petersburg, St. Petersburg, Russia.

Tehmina Bharucha (T)

Oxford Glycobiology Institute, Department of Biochemistry , University of Oxford, Oxford, UK.

Mehrsa Jafarpour (M)

Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London, UK.

Peter N E Young (PNE)

Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Wallenberg Center for Molecular and Translational Medicine, Lund University, Lund, Sweden.

William Jagust (W)

Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Stephen F Carter (SF)

Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Wolfson Molecular Imaging Centre, Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.

Tammaryn Lashley (T)

Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London, UK.
Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.

Lea T Grinberg (LT)

Memory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.
University of São Paulo Medical School, São Paulo, Brazil.
Global Brain Health Institute, San Francisco, CA, USA.

Joana B Pereira (JB)

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Clinical Memory Research Unit, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.

Niklas Mattsson-Carlgren (N)

Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Wallenberg Center for Molecular and Translational Medicine, Lund University, Lund, Sweden.

Nicholas J Ashton (NJ)

Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Wallenberg Center for Molecular and Translational Medicine, Lund University, Lund, Sweden.
King's College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.
NIHR Biomedical Research Centre for Mental Health & Biomedical Research Unit for Dementia at South London & Maudsley NHS Foundation, London, UK.

Jörg Hanrieder (J)

Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London, UK.
Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

Henrik Zetterberg (H)

Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London, UK.
Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
UK Dementia Research Institute at University College London, London, UK.

Michael Schöll (M)

Department of Neurodegenerative Disease, UCL Queen Square, Institute of Neurology, University College London, London, UK.
Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Clinical Memory Research Unit, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.

Ross W Paterson (RW)

Dementia Research Centre, University College London Institute of Neurology, London, UK.

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questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Relevance of biomarkers across different...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Relevance of biomarkers across different...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Relevance of biomarkers across different...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Relevance of biomarkers across different...
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questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Relevance of biomarkers across different...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Relevance of biomarkers across different...