Role of oxidative stress in depression.
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
16
01
2020
revised:
25
04
2020
accepted:
04
05
2020
pubmed:
15
5
2020
medline:
31
8
2021
entrez:
15
5
2020
Statut:
ppublish
Résumé
Reactive oxygen species (ROS) have vital roles in cellular signaling and in defence against invasive microorganisms. Excessive ROS generation and exhaustion of antioxidative defences trigger proinflammatory signaling, damaging vital macromolecules and inducing cellular apoptosis. The failure of cells to maintain redox homeostasis and resultant generation of proinflammatory mediators leads to cell necrosis. The brain is more vulnerable to oxidative stress (OS) because of its higher oxygen consumption, higher lipid content, and weaker antioxidative defence. OS is a main cause of neurodegeneration and its involvement in the pathogenesis of major depressive disorder (MDD) is unequivocally established. OS and proinflammatory signaling have emerged as mainstays in the pathogenesis of MDD. Targeting these changes with suitable antioxidants could be an effective strategy to treat MDD.
Identifiants
pubmed: 32404275
pii: S1359-6446(20)30192-6
doi: 10.1016/j.drudis.2020.05.001
pii:
doi:
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1270-1276Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.