Impact of brain volume and intracranial cerebrospinal fluid volume on the clinical outcome in endovascularly treated stroke patients.
Aged
Aged, 80 and over
Brain
/ diagnostic imaging
Brain Ischemia
/ cerebrospinal fluid
Databases, Factual
Endovascular Procedures
/ adverse effects
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
Predictive Value of Tests
Recovery of Function
Retrospective Studies
Risk Assessment
Risk Factors
Stroke
/ cerebrospinal fluid
Thrombectomy
/ adverse effects
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Acute stroke
Brain volume
Intracranial cerebrospinal fluid volume
Outcome
Thrombectomy
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
17
02
2020
accepted:
22
03
2020
pubmed:
15
5
2020
medline:
6
10
2020
entrez:
15
5
2020
Statut:
ppublish
Résumé
Previously, brain volume (BV) and intracranial cerebrospinal fluid volume (CSFV) have been investigated regarding clinical outcomes of subgroups of ischemic stroke patients. This study aimed to examine if the preexisting, preischemic BV and CSFV have an impact on good functional outcome and mortality in acute ischemic stroke (AIS) patients treated with mechanical thrombectomy (MT). Preischemic BV, CSFV, and CSFV/Total intracranial volume (TICV)-ratio were calculated with a fully automated segmentation platform. Univariate and multivariate analyses were used to study associations. In this retrospective study 107 subsequent AIS patients of a prospective database were included. The segmentation results of the fully automated algorithm based on non-contrast computerized tomography scans (NCCT) correlated significantly with the segmentation results obtained from 3D T1 weighted magnetic resonance images (P < 0.001). In the univariate analysis a preexisting BV (P < 0.001), preexisting CSFV (P = 0.009), and the ratio CSFV/total intracranial volume (P < 0.001) each significantly correlated with good functional outcome and mortality. However, in the multivariate regression analysis, also correcting for patient age, none of these volumes remained to correlate with these outcome parameters. In summary, an association of BV, CSFV, and the CSFV/TICV-ratio with good functional outcome and mortality in AIS treated with MT could not be established. A fully automated segmentation algorithm based on NCCT was successfully developed in-house for calculating the volumes of interest.
Identifiants
pubmed: 32404285
pii: S1052-3057(20)30215-9
doi: 10.1016/j.jstrokecerebrovasdis.2020.104831
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104831Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest BF: Consultant for Stryker, speaker honoraria for Medtronic, Research grant from iSchemaView; CM: Consultant for Stryker and Penumbra. SM, DS, DH, TBB, MB, SW, CZ, and BW declare no competing interests.