Colorectal cancer occurrence and treatment based on changes in intestinal flora.
Cancer
Colorectal
Immune function
Inflammation
Intestinal flora
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
18
02
2020
revised:
29
04
2020
accepted:
05
05
2020
pubmed:
15
5
2020
medline:
4
3
2022
entrez:
15
5
2020
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is the most common cancer in the world, and its incidence has been increasing in recent years. The occurrence of CRC is believed to be related to a variety of factors. Epidemiological data indicate that CRC is mainly affected by environmental factors, eating habits, physical activity and genetic factors. As a newly recognized functional component, the intestinal microbiota plays important roles in preventing CRC formation and maintaining intestinal immunity. In this review, we summarize the mechanisms by which the gut microbiota causes CRC through alterations to immune function, focusing on the mechanisms by which intestinal microbial dysfunction promotes CRC. Furthermore, we describe the changes in the intestinal flora observed in CRC and their potential for CRC treatment with the goal of facilitating future research on the roles of the intestinal flora.
Identifiants
pubmed: 32404293
pii: S1044-579X(20)30100-0
doi: 10.1016/j.semcancer.2020.05.004
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Prebiotics
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3-10Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.